<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31788

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMSTNNTTTNNEDLISSLYPPPPPYYKFFTKDNLQKLSTWQENNQTTTVSSEVKLEEENTDPDSNNSEENSIPPGELRFLIPPKQPEGPQYRGYGNIWLFEDKLPNLKDSQWEQLYNTSTSTFTSTSTSTANTNIITNTDTDINGNQEVDAGDSTGDENLTSETKIKELHKLMDSLLLNFLELIGILSIDPIKYDKKIHDINLILININHLLNTYRPHQSRESLIMLLKNQIDYKFLEIDQINKKCLDIKSKIKNLINERITVVSDGTTTNTTTTTKTTGLGDGDSIDEKEQLKQDIINRLLSSI
Length304
PositionMiddle
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.06
Grand average of hydropathy-0.717
Instability index34.02
Isoelectric point4.70
Molecular weight34508.00
Publications
PubMed=15123810
PubMed=17419877
PubMed=24025428

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31788
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.45|      24|      71|      27|      50|       2
---------------------------------------------------------------------------
   27-   50 (42.98/22.16)	FFTKDNLQKL..STWQE..NNQTTTVSS
   97-  124 (35.47/17.21)	WLFEDKLPNLkdSQWEQlyNTSTSTFTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      56.14|      11|      77|      58|      68|       4
---------------------------------------------------------------------------
   58-   68 (19.84/ 9.34)	NTDPDSNNSEE
  137-  147 (19.62/ 9.16)	NTDTDINGNQE
  152-  162 (16.69/ 6.77)	DSTGDENLTSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31788 with Med7 domain of Kingdom Fungi
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