Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MAESGQPSALTTAFAPPPPLWKHFTPENVKRLEEIKKEASKGEDGKPRKKTWTPAELRALDLPPELRFLVPPEVPTEGHYSVFGELQSLSTALPSLKDQGIEQLYPSSPAAESGRDTSEPSKPLNHAYYLLKISKSLLLNFLEFVGVLSICPEQFESKVNDLRNLFINAHHLLNLYRPHQARESLIMMMEEQLSQSREEIQQMDKLKAEITDALDRLRRQGVDVDSAAGAAVQEEKPTTAEAQISDHSRLVWDLLDGDN |
Length | 259 |
Position | Middle |
Organism | Aspergillus terreus (strain NIH 2624 / FGSC A1156) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.545 |
Instability index | 55.39 |
Isoelectric point | 5.19 |
Molecular weight | 29060.54 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP31783 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.61| 16| 45| 13| 29| 1 --------------------------------------------------------------------------- 13- 29 (27.43/18.95) AFAPPPPLwKHFTPENV 59- 74 (29.19/14.41) ALDLPPEL.RFLVPPEV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KPRKKTWTPAELRALDLPPELRFLV 2) PLWKHFTPENVKRLEEIKKEASKGE | 46 19 | 70 43 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab