Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAFDPAANAGPPLDEIQWHTPPQFEAGIHSNSILYYFAQSPFYDKTSNNEVVFQQGLNNQAMSQYLATRELFESRLKEMSGLEFIVAQEPAETGPGMGTGVWVINKQTRRKRPPTNPARPEDGPPDEIIVHSVYFVVGENIYMAPTLADVLSSRIGAIATAITKTIPLVDEVSDWAPAVGRRYITPAQPSAGAGAASGTTNYTASRTATPLPDGLPSTATTNKPGAKAGGGTTTNDPLLDSLLMEEALLTHERYGTEYMDENPITGKPGDFHLTSTGRKTQTKSALTLKEAAAALPALNTKGLGAAGSNPLAKGAAAAAAANANAVTGKETKSPKTPGGGGPPKPKRRKSKNVITTPGAA |
Length | 360 |
Position | Head |
Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.412 |
Instability index | 41.68 |
Isoelectric point | 7.84 |
Molecular weight | 37735.95 |
Publications | PubMed=12655011 PubMed=12712197 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coactivator activity GO:0003713 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP31768 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 135.82| 43| 108| 186| 231| 1 --------------------------------------------------------------------------- 188- 231 (73.99/38.55) QPSAGAGAASGTTNYTASrTATPLPDGLPSTATTN..........KPGAKAGGG 289- 341 (61.83/23.71) KEAAAALPALNTKGLGAA.GSNPLAKGAAAAAAANanavtgketkSPKTPGGGG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.71| 15| 110| 4| 19| 2 --------------------------------------------------------------------------- 4- 19 (28.41/22.05) DPA.ANAGPPlDEIQWH 116- 131 (27.30/15.84) NPArPEDGPP.DEIIVH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAAAAAANANAVTGKETKSPKTPGGGGPPKPKRRKSKNVITTP 2) ILYYFA | 315 33 | 357 38 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab