<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31765

Description Isoform 3 of Mediator of RNA polymerase II transcription subunit 6
SequenceMAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ
Length181
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.09
Grand average of hydropathy-0.559
Instability index50.39
Isoelectric point8.71
Molecular weight28424.27
Publications
PubMed=9734358
PubMed=14702039
PubMed=12508121
PubMed=15489334
PubMed=10508479
PubMed=10235267
PubMed=10024883
PubMed=10993082
PubMed=11867769
PubMed=15175163
PubMed=15989967
PubMed=16574658
PubMed=16595664
PubMed=17000779
PubMed=19608861
PubMed=21269460
PubMed=25944712
PubMed=28112733

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000269	PubMed:16595664
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:MGI
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	IDA:HPA
nucleus	GO:0005634	TAS:ProtInc
GO - Biological Function
transcription coactivator activity	GO:0003713	IDA:MGI
transcription factor binding	GO:0008134	IPI:UniProtKB
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:MGI
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome

Interaction

Binary Interactions
[O75586<-->Q13616: CUL1]	NbExp=2	EBI-394624,EBI-359390
[O75586<-->Q9NVC6: MED17]	NbExp=2	EBI-394624,EBI-394562
[O75586<-->Q9BUE0: MED18]	NbExp=3	EBI-394624,EBI-394640
[O75586<-->Q6P2C8: MED27]	NbExp=2	EBI-394624,EBI-394603
[O75586<-->Q9NX70: MED29]	NbExp=3	EBI-394624,EBI-394656
[O75586<-->Q9R0X0: Med20]	Xeno	NbExp=2,
[O75586<-->Q9D7W5: Med8]	Xeno	NbExp=2,

Repeat regions

Repeats

>MDP31765
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.73|      17|      22|     189|     207|       1
---------------------------------------------------------------------------
  189-  207 (29.66/22.54)	P.PKFVqlKPGEKPVP..VDQT
  213-  232 (23.08/11.33)	PiPETV..KPEEKETTknVQQT
---------------------------------------------------------------------------

Associated diseases

Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31765 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ
195
246










Molecular Recognition Features






MoRF SequenceStartStop




1) KNVQQTV
2) PPEKRMRLQ
3) TKKEAEPIPETVKPEE
227
238
207
233
246
222