<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31762

Description Putative mediator of RNA polymerase II transcription subunit 6
SequenceMEDFNNDDPMNFDKDDMINNNNDNNNNNNDNDNNNENNEDSNNNSNLENMISDTSTPRILEEEPDLTQVMWRDPLWLQMYPLNPQTILQYFSYSQFYDKNCNNEQLKMQRLDLSALKNMDGLEYELIKFVEPSFFLIAKQTRISPTDVLINTLYYVINGNIYQAPELHVVFKSRVSQSISHLSEAFNSISSIVNWDIVNGYSLNLDPSNQQEKSKLAAYSRKQIEDTKRLDQLINSLFIKFPAINRPVENPQQMGGGITPQQQPSQP
Length267
PositionHead
OrganismDictyostelium discoideum (Slime mold)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales> Dictyosteliaceae> Dictyostelium.
Aromaticity0.09
Grand average of hydropathy-0.807
Instability index46.14
Isoelectric point4.40
Molecular weight30945.87
Publications
PubMed=15875012
PubMed=18515835

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISS:dictyBase

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31762
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      20|      31|     124|     144|       1
---------------------------------------------------------------------------
  124-  144 (29.47/21.08)	YELIK...FVEPSFFLIAKqTRIS
  154-  176 (30.18/16.99)	YYVINgniYQAPELHVVFK.SRVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.45|      11|      15|       1|      11|       2
---------------------------------------------------------------------------
    1-   11 (23.41/ 9.78)	MEDFNNDDPMN
   17-   27 (21.05/ 8.12)	MINNNNDNNNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31762 with Med6 domain of Kingdom Amoebozoa
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