<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31760

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMATVDLRDNLLGISWVDSGWVPILNPSNVLEYFSERSNPFYDRTCNNEVVKMQRSTLDHLTQLVGVEYILLHTQEPILYIIRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGSVISSRALSAVHGIQSAFDEAMSFCRYHPSKGYWWHFKDQEEKERVKPKSKRKEEPSSLFQRQRVDTLLLDLRNKFPPTFYQTKPGEKPVPVEVKKEPEVPVETVKPQEERETKPPAPPAPPRPPPQTTPNKPPPEKRARVQ
Length254
PositionHead
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.09
Grand average of hydropathy-0.710
Instability index61.81
Isoelectric point8.91
Molecular weight29250.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31760
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.02|      11|      18|      79|      89|       1
---------------------------------------------------------------------------
   79-   89 (20.77/13.75)	YIIRKQQRQSP
   99-  109 (20.25/13.24)	YIIAGVVYQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.47|      12|      44|     189|     203|       3
---------------------------------------------------------------------------
  189-  203 (17.05/13.52)	PPTfyQTKPgEKPVP
  236-  247 (28.43/10.62)	PPP..QTTP.NKPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.30|      13|      57|     156|     168|       4
---------------------------------------------------------------------------
  156-  168 (23.64/12.44)	ERVKPKSKRKEEP
  215-  227 (21.66/10.84)	ETVKPQEERETKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31760 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PTFYQTKPGEKPVPVEVKKEPEVPVETVKPQEERETKPPAPPAPPRPPPQTTPNKPPPEKRARVQ
190
254










Molecular Recognition Features






MoRF SequenceStartStop




1) PEKRARVQ
2) PEVPVETVKPQEERETK
247
210
254
226