<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31755

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMMPRMGPPAAARQDNPLHVSFRNPQWPPNFINKDNVLDYFCNQANAFYEMNSCNQQIRMQNIVNRTVEECLRTMPGIQYVLWYSQPPLFIICKQRRNNVTNVSPIAYYYVINGSVHQAPDMYSLVQSRLLGALEPLRNAFGEVTNYSRYNTAKGYYWEFKNKPNVKKREEEKKEDEEEKLEDRSTNFQKTRTMMLLNQLFSEMPAEDALEREEKEEVEEEEEETLKTEEPTTSTDEPKFAEPTARTTSKQ
Length250
PositionHead
OrganismCaenorhabditis elegans
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis.
Aromaticity0.10
Grand average of hydropathy-0.944
Instability index63.63
Isoelectric point5.11
Molecular weight29406.67
Publications
PubMed=9851916
PubMed=9234719
PubMed=10611325
PubMed=11728440
PubMed=15790964
PubMed=28603670

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Acts to repress beta-catenin target genes. Required for asymmetric division of T-cells and for gonad and germ cell development. 
ECO:0000250	
ECO:0000269	PubMed:10611325
ECO:0000269	PubMed:11728440
ECO:0000269	PubMed:15790964
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central
GO - Biological Process
multicellular organism development	GO:0007275	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions
[Q9N337<-->P16356: ama-1]	NbExp=2	EBI-1533827,EBI-1533906

Repeat regions

Repeats

>MDP31755
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.39|      38|      40|     144|     181|       1
---------------------------------------------------------------------------
  144-  181 (66.66/35.28)	TNYSRYNTA...KGYYWEFKNKPNVKKREEEKKEDEEE...KLE
  185-  228 (52.74/26.65)	TNFQKTRTMmllNQLFSEMPAEDALEREEKEEVEEEEEetlKTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.48|      16|      17|       7|      23|       2
---------------------------------------------------------------------------
    7-   23 (26.77/24.17)	PPAAARQDNPLHVsFRN
   27-   42 (32.70/24.07)	PPNFINKDNVLDY.FCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.96|      10|      38|      53|      64|       3
---------------------------------------------------------------------------
   53-   64 (15.36/16.31)	CNQqiRMQNIVN
   92-  101 (19.60/12.45)	CKQ..RRNNVTN
---------------------------------------------------------------------------


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP31755 with Med6 domain of Kingdom Metazoa



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MMLLNQLFSEMPAEDALEREEKEEVEEEEEETLKTEEPTTSTDEPKFAEPTARTTSKQ
193
250










Molecular Recognition Features






MoRF SequenceStartStop




1) LEREEK
2) PKFAEPTAR
3) YYWEFK
209
237
155
214
245
160