<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31745
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MEKESVYNLALKCAERQLTSMEFSNLYKEFFNEKFPSLIQEEEEDTTTTANINEVKKASDLVDTPSNNTAATADTTHLHEALDIVCSDFVKILNLEKPLILADYIVEVLLVNYNSDMIKCFLPKLNSVRNSLLLAHFFSKSCSFFAKLSDTLIIDQVRKDLGNVIVPNILSLDMNSMNKELIAIVSKLLQTTLKLSPSPILLTSAGCKNGSFTLLNQLSQTNKLLFKRVSQTFEAKLHFKDTKPFLNKDSTNEFVGSPSLTSPQYIPSPLSSTKPPGSVNSAAKYKDMKLLRYYKNIWLNNKIINWEISNPDFLSKYSAITSSIFQESFNSVQNLDQLLTDLIETSFTCFAQFVSNKQYHQANSNLTLLERKWVIFITKHLPLLILENSSRSPRVVTNALDNIDEKVVKAIRIYFTEKDDNKTNNEDLFDDYPSTSLDIRHDFIKGLIMLNLQPASVINNYLREDQMIDTSILPTRDDLFVRNLQGIQEVVHNTNSFIISSLDTLELESITESITHDSSNGLFQVLHNFESVAPTKQREIVKAFLSIFEDAIKELNYNRIAKICALLFFNFSHSLTTILSFSSPAALMKTLIKFVDLSRNGRNGSNGNDESSEYETINISLSFSWAILLIINLTQTYGISVVDVALKYPELSIKNSFIINFISNLPNVSDKYYLEESNVNDSDMLTKSHNTVQSWLCDLFVNGSITDQLIQNIETRQLANLIPFIVKQVLLSVEIGVLTDISSLIGGFEYFLQPLLLVGLIKTFYWLEQFLSCVKNDTISEDILQGIFNLLNTLFNPVTLNEDSKAFHTAVLRLNAIPLLKVLRKFRVQSQSNYGIYSSDAQGDPNLEPLIAKLVAVLNVSPVYDVDPRIINSENDYSRKQLGYGKFLILNENPINKIMTNQINSFWSLHSSTYYNLDYLFELIELVTPKSFLFDVLKTLEYKLATYGVPGSENKRGSLDSEHVFDYFFYFLVLYDVKTAEEASQLIEYMENDAKKSKGDVDIKGEDLHEKNDSAEVRQETQPKAEATQDDDFDMLFGENDTSTQAYEEEEENEDNDGNNRTNNVPMIKAEETPSKTNKISILKRHSFAVLLHERKLLNDLALENGEITKTENEKFISYHDKYLCMLKTCVF |
Length | 1132 |
Position | Tail |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Saccharomyces.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.192 |
Instability index | 36.60 |
Isoelectric point | 5.00 |
Molecular weight | 128792.84 |
Publications | PubMed=8585324
PubMed=9169869
PubMed=24374639
PubMed=9812975
PubMed=9671481
PubMed=14562095
PubMed=14562106
PubMed=14623974
PubMed=15175151
PubMed=15477388
PubMed=16002404
PubMed=16076843
PubMed=16109375
PubMed=16263706
PubMed=16429153
PubMed=17192271
PubMed=18407956
PubMed=12191485
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. The Mediator complex, having a compact
conformation in its free form, is recruited to promoters by direct
interactions with regulatory proteins and serves for the assembly of a
functional preinitiation complex with RNA polymerase II and the general
transcription factors. The Mediator complex unfolds to an extended
conformation and partially surrounds RNA polymerase II, specifically
interacting with the unphosphorylated form of the C-terminal domain
(CTD) of RNA polymerase II. The Mediator complex dissociates from the
RNA polymerase II holoenzyme and stays at the promoter when
transcriptional elongation begins.
ECO:0000269 PubMed:16076843
ECO:0000269 PubMed:16109375
ECO:0000269 PubMed:16263706
ECO:0000269 PubMed:9671481
|
GO - Cellular Component | mediator complex GO:0016592 IDA:SGD
mitochondrion GO:0005739 HDA:SGD
nucleus GO:0005634 IDA:SGD
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | histone H3 acetylation GO:0043966 IMSGD
regulation of transcription by RNA polymerase II GO:0006357 IMSGD
transcription by RNA polymerase II GO:0006366 IDA:SGD
|
Interaction
Repeat regions
Repeats |
>MDP31745
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 98.43| 27| 67| 124| 151| 1
---------------------------------------------------------------------------
124- 151 (41.61/28.92) KLNSVrNSLLLAHFFSKSCSF..FAKLSDT
173- 196 (31.91/16.75) DMNSM.NKELIA.IVSKLLQT..TLKLS..
198- 221 (24.91/11.12) ......SPILLTSAGCKNGSFtlLNQLSQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 407.99| 141| 352| 224| 387| 2
---------------------------------------------------------------------------
224- 387 (206.89/174.24) LLFKRVSQTFEAKLHFKDTKPF.........LNKDSTNEFVGSPSLTSPQYIPSPLS.S.........TKPPG..SVNSAAKYKDMKLlryyKNIWlnnkIINWeISN.PDFLSKY....SAIT.SSIFQESFNSVQNldqLLTDL.IETSFTcfAQFVSNKQYHQansnLTLLerkwVIFITKHLpLLILE
566- 734 (201.10/116.45) LLFFNFSHSLTTILSFSSPAALmktlikfvdLSRNGRNGSNGNDESSEYETINISLSfSwailliinlTQTYGisVVDVALKYPELSI....KNSF....IINF.ISNlPNVSDKYyleeSNVNdSDMLTKSHNTVQS...WLCDLfVNGSIT..DQLIQNIETRQ....LANL....IPFIVKQV.LLSVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.40| 14| 21| 49| 62| 4
---------------------------------------------------------------------------
49- 62 (21.94/16.45) TANINEVKKASDLV
72- 85 (23.46/18.18) TADTTHLHEALDIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 147.15| 48| 408| 476| 530| 5
---------------------------------------------------------------------------
483- 530 (80.54/49.97) NLQGIQEVVHN.TNSF.IISSLDTLELESITESITHDSSNG.LFQVLHNFE
891- 941 (66.62/29.47) NENPINKIMTNqINSFwSLHSSTYYNLDYLFELIELVTPKSfLFDVLKTLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.06| 29| 352| 88| 123| 6
---------------------------------------------------------------------------
88- 123 (45.37/37.25) DFVK...ILNLEKPLILADYIVEvllvnynSDMI.KCFLP
442- 474 (42.69/22.32) DFIKgliMLNLQPASVINNYLRE.......DQMIdTSILP
---------------------------------------------------------------------------
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