<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31741

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMCVPAKQGTLHAKSPLPGLKIAGLLLRPRAANASSVDPRVIIYLERLLALKKVDASDVLSSAFQYSKDRLPKTGDDGSSKDSGWHNPPELEEVVFHRLSKAFQAEERPVNSTEGLRTLVVVTRWMQTMVTSHTSDTMIQAMAGIQQQPQQQSINVREGLGMLVVGVIENQKMLNILNKHHIKNCKSPGRSRKSNTTFTTNLATGEWRSERRSRTETQDLKSLRSNFEAVDWIFPTINTRAGLYIFLNSLIDSQNMATDLITAAFDILANAMYRSEPSQNMFCLKSFLINKIPILLLQISSSMFPMTAELSITQALSHVDPNAFPAFSQGFDDMLGNTNSLADVRQDFLNACALHGLITTATVERLLGETPMQGPPGTKYDKSTLLEQCKSNFDKISMYIDELDNLDGNAGAIVGAIAEFIPHLCETQMTMYLKQLSSLLFKKPQAIDVILQFTSPASILRPLCQILDDWHYDSDQGEYQPVYDEFGAVLVLVMTFMYRYDLTYHDIGIGAESFVARLMTKGNQSMLPDEMTDEQSKHLGHWLKGLYDAGNEGLSNDVFASCSPREFYFIVPTLFKQTVMALSAGILTFESVKGGLEYLMETFLLPSLIGGLIWMSSYALIQSHSDLDAIMRIFREVISSAPSSGDAQAMHSTILSIVSSRLEKCLRTIQRRDASRANSIEPLIQAIKGNLHSERSMFASMKELEQWTNAPNSTLHTSLRHTVQQLSQWASTSSIQPNPPSYTHRQVYVSLKIMGASKVIKAIVDELKAQTEASNGAAALDVGVSIICAPTVDDSPVPVAWLSSPIPASNPPRTRLNLREMLKHEFDNAAALVATDPLAAETVVRLHRRVEAQLSSIAENALQGHGSVLNLPNVNMGDMQSQSIPDDITKAIDDAAAASIADDITTMDNKALQRSMDDLTGPDGLDLSSIGMGTGDAGTGDMGAELGNLPDLDLGDMSGMGMDMDMDMAMGGGGDDDWGLDFDNM
Length984
PositionTail
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Phaeosphaeriaceae> Parastagonospora.
Aromaticity0.06
Grand average of hydropathy-0.152
Instability index44.39
Isoelectric point5.08
Molecular weight107929.78
Publications
PubMed=18024570

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31741
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     144.51|      26|      34|     923|     948|       1
---------------------------------------------------------------------------
  852-  870 (23.27/ 8.11)	..QLSS......I...AENALQG.HGSVL.NL
  876-  906 (29.86/12.26)	G.DMQSqsipddITKAIDDAAAASIADDITTM
  923-  948 (45.01/21.80)	GLDLSS......IGMGTGDAGTGDMGAELGNL
  960-  984 (46.36/22.65)	GMDM.D......MDMAMGGGGDDDWGLDFDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.76|      32|      33|     602|     634|       2
---------------------------------------------------------------------------
  568-  600 (35.30/14.74)	F.IVPTLFKQTVMALSAGI.LTFESvkgGLEYLME...
  602-  633 (54.74/28.34)	F.LLPSLIGGLIWMSSYAL.IQSHS...DLDAIMR.IF
  637-  669 (34.72/15.57)	IsSAPSS.GDAQAMHSTILsIVS.S...RLEKCLRtIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.69|      17|      36|      59|      77|       3
---------------------------------------------------------------------------
   59-   77 (22.51/23.24)	LSSAFQySKDRlPKTGDDG
   98-  114 (30.18/18.72)	LSKAFQ.AEER.PVNSTEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.70|      15|      33|     388|     405|       4
---------------------------------------------------------------------------
  388-  405 (21.56/23.70)	CKSnfdKISMYIDELDNL
  424-  438 (27.13/18.06)	CET...QMTMYLKQLSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.86|      27|      33|     748|     774|       6
---------------------------------------------------------------------------
  748-  774 (42.19/31.87)	VSLKIMGASKVIKAIVD..ELKAQTEASN
  781-  809 (44.67/34.24)	VGVSIICAPTVDDSPVPvaWLSSPIPASN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31741 with Med5 domain of Kingdom Fungi
Unable to open file!