<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31737

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMASSTATVSLHNLVKLCCKRNSTSKVFVSLYNQLEEKSPIQDNDYLSNLLQPDIKNKSKRESSLITEYILALAISSESQLEKFWKFLPEILLENQIHYMIELNSILLSKSNIERPSSDIFKEIVNNCFFKYTSSYISSLFPGISATQVSLLNHIIVVWCSVIRRSPFHLNTSSFKQLAVKIVSVLTECDLRNSLNYFISNTSSILNTDDLQVDSVQDSDDKKIAAIRSTTTIQLVNNISSINPKSRKATQLNVIKRYLWLNSIMKNWKFSNDVFLKQFEQNFLPNSSNNLKKPYVLAFELICAFFKGIVTSICSNESKYVLFNWKNFIITRLPTLLNDIKFTTSHVAPTSNDSSFKQETLDDAIINAFESFEDPVNKVLTQFSIDNLSICDLRQTFIKSCIYNKLIPVMSYHKIFTADNTVTDQFLNNGIEQVGQITSIRDEFETKLLNINTEFTTLEDSGLIEYINSLPGLLEFSATKQLELSETVDQVIEHLIDEKNIEKLYRLLLSVCNNLTTLNLICFNSNCGPFSILYKLINYIDNEDFNVDDDDNFQETYAFFGIIILAILLIIETFKIDYSQITVTNSYIVDYINEFYYRLCDSLTNISTSDTEEDNTIISNYNDLISDWINALFDDNNDGLSDDLIKSVNVKQIYKMIPIIYQQSIIATNSNKIDIKILNNGIDYLSQMFLIPCTLNIIKWLLRRIWADDPTLDCLPVQVLHELIKSNMGESDEPTSESKLFFQIVLKISGNSIISTLKKLNNWENSNLIKDIIEKVSNSVDPMYLENDLSIKLNERVNLYEQLKTNVINLVNNMNIYDYQFLNIFSSIDRDNELIRYIVEEITSYQKTNGGNEDTKLFINLSIFMILLDAIDNDDDKQYWIKRIKDTMVPVSSNSSGENRFDISMDYHYSSIFNNSDETSNNDYLFSGENNNSSVEIEGLKRKIGRHESLLNSFNKIKEFCDTEVQSTFVKSLRTFRDKLINELEVFTLNV
Length990
PositionTail
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Debaryomyces.
Aromaticity0.10
Grand average of hydropathy-0.159
Instability index39.89
Isoelectric point4.82
Molecular weight113958.14
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31737
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     736.97|     174|     182|      57|     237|       1
---------------------------------------------------------------------------
   57-  205 (229.72/110.87)	......................................KSKRESSL..ITEY.ILALAISseSQLEKFWKFLPEILLENQ..IHYMIELNSILL.SKSNIERPSSDIFKEIVNNC.FFK........YTSS....YISSLF....PGI...SAT.QV.SLLN.HIIVVWCSVIRRSPFHL.NTSSFKQ..LAVKIVS...........VLTE........CDLRNSLNY..FISNTS..SIL
  206-  402 (188.70/94.65)	NTDDLQVDsvqdsDDKKIAAIRSTTTIQLVNNissinpKSRKATQLnvIKRY..LWL.....NSIMKNWKFSNDVFLKQ.......FEQNFLPN.SSNNLKKPYVLAF.ELI..CaFFKgivtsicsNESK....YV..LF..nwKNF...IIT.RLpTLLN.D.IKFTTSHV..APTS..NDSSFKQetLDDAIINafesfedpvnkVLTQfsidnlsiCDLRQT.....FIK..S..CIY
  403-  532 (150.96/68.49)	N...............KLIPVMSYHKIFTADN......................................TVTDQFLNNG..IEQVGQITSI....RDEFE...TKLLN..INTE.FTT........LEDSglieYINSL.....PGLlefSATkQL.ELSE.TVD....QVIE....HLiDEKNIEK..LYRLLLS...........V...........CNNLTTLNLicFNSNCGpfSIL
  540-  694 (167.59/76.80)	DNEDFNVD.....DDDNFQETYAFFGI.........................iILAILLI....IETFKIDYSQITVTNSyiVDYINEFYYRLCdSLTNISTSDTEEDNTIISN..YND........LISD....WINALFddnnDGL...SDD.LI.KSVNvKQIYKMIPIIYQQSI.I.ATNS.NK..IDIKILN..ngidylsqmFLIP........CTL...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      14|      18|     893|     909|       3
---------------------------------------------------------------------------
  893-  909 (22.17/19.66)	NSSGENRfdiSMDYHYS
  913-  926 (25.90/13.54)	NNSDETS...NNDYLFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31737 with Med5 domain of Kingdom Fungi
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