<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31735

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMESKSLNTLALRCAARKIPASEFLNLYKEFYNETFPANSIDNDDAKTQEGSGSQDKTDVEESISKPVGSKNDPVAILCAEFMKLLENGKYVILADYVVEVLFVNYHSELVREFLPKLKDLMNKGILIHFFSKSCAFFVNLTDNLVISQLIKDLRATIVPCILETNFCDISNELVVAIAKFLQAVLRFTPQPIQINSETYRDNTFNLTKRLSLINKILSKKFAGIIDKKLQFKEVLGPFTKDSTLDFDNSPSITSPQFIPSPLPSMKERSVTSSQSAIKYKDLKLLRYYKNIWLNSKLMNWQPFDSEFISNYSAIKSSLYPDQVQNIQNVDLLFTDLIETAFTCFAQFVSNKLYHQSNSTYNLLERKWILFLSKILPLLVYKNSSRTAHVIGNALDGIDDKVIKAISAYYQENDDGRSRNDDLFDDYPSTSLDIRHDFIKSLTMLGVVPPVFITNYLRGDQTVDSKALATTDDLTFTNQQGIIEIVNDIPNFIRSSLEGMEMENVSEPTLVSSNGLLQVLSNFDTVSPTKQFELANAIVDMLSESSTTFELNTFVKLTAVLTFNYSHSLTSILMYVTPEVLTKLYLEFVDKHWNSQVIGKQETDGESQFENVNISMSFSWAILMLTILYKQYHIDFVSMRADYTTDNIKNSFAITFVENLPDISDLFFIDEKNSDDPEVQVKSHKLVRDWLNDLFVNGSLSDSLLQNIEPKQLAILVPYIFKQVTLAMEIGAVGDLQNLIGGFEYFLQPFMLVGLIKVMYWLEQYLSCLKSDETDEKLIQKVLSLLNTIICPSTLNEDSKAFHFAVLRLNAIPLLGILYQFRSNKHAESNYGIYSSDNEGNPTLELMISRLISSLSISPVYDIDSTILVTDNNFVQKPPKFQSFFVTNEISMNKMLTNQMNSFWSLHSSTYYNLDFLKTLIDTLTPKQFLLDVLRTLEYKVETLGVKDVRNKSSSNESDQVIDYLFYFLVLYDIENSEDAKAMAQFMEDTVDISINGDSGIVKQETQPKSEYNPDDDIDMLFGENDTSMQANEEDTLDNKELKSDRNCALGKNRHTFGFIIHEIKLSYGTLESDSMSYEDYKKICEYHSRYLKMLKTCIF
Length1099
PositionTail
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Nakaseomyces> Nakaseomyces/Candida clade.
Aromaticity0.11
Grand average of hydropathy-0.161
Instability index39.28
Isoelectric point4.84
Molecular weight125496.50
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
histone H3 acetylation	GO:0043966	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblFungi
transcription by RNA polymerase II	GO:0006366	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31735
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     782.18|     173|     177|     409|     583|       1
---------------------------------------------------------------------------
  246-  414 (179.25/120.17)	........FDNSPSIT.................SPQFIPSP..LPSmkERSVTSS.QSAIKyKDLKLLRYYKNIWLNSKLMNWqpfdsefisnysaIKSSLYPDQVQNIQNVDL.LFTDLIETAFTC............FAQFVS..........NKLYHQSNST..YNLLE.....RKWILF......L..SKILPLLVYKNSsrtaHVIGNALDGI....DDKVikaISAYYQENDD
  415-  589 (265.44/189.20)	GRSRNDdlFDDYPSTSLDIRHDFIKSLTMLGVVPPVFITNY..LRG..DQTVDSK.ALATT.DDLTFTNQQGIIEIVNDIPNF.............IRSSLEGMEMENVSEPTL.VSSNGLLQVLSN............FDTVSP..........TKQFELANAI..VDMLS.....ESSTTFE..LNTF..VKLTAVLTFNYS....HSLTSILMYV....TPEV...LTKLYLEFVD
  598-  779 (168.68/113.10)	GKQETD...GESQFENVNISMSFSWAILMLTILYKQYHIDFvsMRA..DY.........TT.DNI...KNSFAITFVENLPDI...............SDLFFIDEKNSDDPEVqVKSHKLVRDWLNdlfvngslsdslLQNIEPkqlailvpyiFKQVTLAMEIgaVGDLQ.....NLIGGFEyfLQPFmlVGLIKVM...Y......WLEQYLSCLksdeTDEK...LIQ.......
  791-  933 (168.81/112.62)	............PSTLNEDSKAFHFAVLRLNAIPLLGILYQ..FRS..NKHAESNyGIYSS.DN....EGNPTLELM..ISRL.............I.SSLSISPVYDIDSTIL.VTDNNFVQKPPK............FQSFFV..........TNEISMNKML..TNQMNsfwslHSSTYYN..LD.F..LK.TLIDTLTPK....QFLLDVL........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.22|      25|     556|     136|     161|       2
---------------------------------------------------------------------------
  101-  125 (42.14/26.84)	LFVNYHSEL.VREFLPKLKDLMNKGI
  136-  161 (37.07/27.52)	FFVNLTDNLvISQLIKDLRATIVPCI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31735 with Med5 domain of Kingdom Fungi
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