<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31734

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMASTEQWGAFLHQCLAHRIDVADFKNLSRLLFKRNPIAQGALIDVVLETRLAAGIKWDPLLPLYIDGLCKMGKLQISTVLAALLKHSSIHEKPGTDAAAAKQKQKCYTLMTDIRVIQDAMLAVSTGHAPKSLSETAGTFLAIADWIHAVVSWHHGQMNASQQAEGLMSSPDAVSLFESLGILLAAVSGTEKGLQVLSSDSNEGLKVKLGHALSAYLPLCVDLSLPLRNRLDALQKEFNLYGEPPPKNLGVSSLENLHVNGIQFEASIIDGPAINSRAGLYVYINAMLAGRPLVDDSMLLNYLTNRYGAHYDVLIQDLITAAFDVCSNAMYRNESSRTMFLFRSFLVNKLPSFFAAMLSASMVSIPMELCISHALSRLDPNTFPSFSQMFSMQGNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQALPVGYNKDDLVSQINTTPERAEQLINEIEFTEGNAGPIVGAITEVMQNLCNQKETMTLKNICNSLSRRPQALDVILLFRSPKQVLQPLCALLDSWHWDEDQGESQPVYDEFGSILLLVLVFKYRYDLSAYDLGIANNDSFVLRLLERGSSSQKLDELSESQNKHLGSWIGALFIAEGISEETMSACSPQEFYLLASTLFSQSLAACEAGKLEFETLKGGFEYLLEPFLLPSLVVALTWLGNHIWEAESDPSIPLKALHSLVSPSSISGEAKEIHRTVLNITARSLDEQLKDVRARHPSRTDIKPILDVLEPCLSFPRTGSCHRSELETWTTHAGNLLGSIRSTMQSLVLWCTSPDVNIPPPSYTHRQLVAGIRIVGATRLLAALLDELRLQTDANNGDLALDIAASLVCAPLPESFAVESSPYHPVAVDLAKDPVPRCPLLTLRDALALQHEAVPRTAEKDPARAEAVVRLYRRVAALAAPTAQVPNLDMNNLIQNMQLGVGVDGHDQMGLPAGGAGDAVGDEPNLDQMLDNAAAAAAAGIDSGVGQGMGGDMSGGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1016
PositionTail
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.06
Grand average of hydropathy0.032
Instability index43.43
Isoelectric point4.96
Molecular weight110457.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31734
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     294.64|      95|     297|     457|     560|       1
---------------------------------------------------------------------------
  457-  560 (142.55/124.11)	EIEFTEGNAGPIVGAITEVMQNL...CNQKEtmtLkNI.CNSLSRRpQALDVILLFRSPKqVlqpLCALLDSWHWDEDQGESQPVYDEFGSILLLVLVFKYRYDLSAY
  755-  853 (152.09/101.32)	ELETWTTHAGNLLGSIRSTMQSLvlwCTSPD...V.NIpPPSYTHR.QLVAGIRIVGATR.L...LAALLDELRLQTDANNGDLALDIAASLVCAPLPESFAVESSPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.69|      29|     297|       4|      32|       2
---------------------------------------------------------------------------
    4-   32 (53.54/42.78)	TEQWGA....FLHQCLAHRIDV...ADFKN.LSRLLF
  303-  339 (36.15/26.16)	TNRYGAhydvLIQDLITAAFDVcsnAMYRNeSSRTMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.95|      25|     616|      36|      63|       6
---------------------------------------------------------------------------
   36-   63 (32.59/30.63)	PIAQGALIdVVLeTRLAAGIkW....DPLLPL
  656-  684 (44.36/25.74)	PFLLPSLV.VAL.TWLGNHI.WeaesDPSIPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31734 with Med5 domain of Kingdom Fungi
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