<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31732

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSPVQWGTFFHQCLLHRIDANEFRNLSKLLLQKCPIAETALLDALLQTRSESRIKWDPLLPLYIDCLCRTGRVRTSTVLTSLLKYSSIHDKPQLSTSEGKDGSKCYTLMTDIRVIQDTMLSVSTGSTPKTNAEAVAIFFAIIDWIHAVASWHNSHFDPGQHSSGIMSSPDVVSLFESLGILLAALSGTGKGLEVLSADSHEGLKVKLGQALSAYLPLCVEVSLPLRNRLDGLQKEFNLYGERVPKSLDVPMMENMNVNALQFEASVMDGPVINSRAGLYVFINAMLVGRPLVDDGMLINYLANRYGGHYEALVEEILTASFDVLSNGMYRNESSRMMFVFRSFLVNKLPPFFAAMLASTMVSIPMEMCISHALSRLDPNTFPSFSQMFEMQGNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGYNKDELVSQINANPERAEQLINEIESMEGNAGAIIGAITEVMHNLCNQKETMTLKNICNSLSRRPQALDVVLIFRNPKQVLQPLCALLDSWHWDEDQGEYQPVYDEFGSILLLVLAFKYRFDLRPADLGISSSDSFVLRLLERGSCSQKLDALDEKQNKNLGSWIAALFIAEGISEETMSACSPQEFYLLVATLFSQSLEACETGKLEFDTLKGGFEYLLEPFLLPSLIFALTWLGDHIWEMELDPSIPLKVLHSLVNPSSISGEAREIHRTVLNIAARTLEEQLKDVRTRHPSRTDIKPILDSLEPCLSFQLVGSSHRSELEGWTTHSSGGLLGSIRSTFQSLVLWSTNPEVSMAPPPYTHRQLIAGVRMLGASRVLPALIEELKLQTEAGNGPLALDLAATLICAPMAETFSVEQNSHQPVDPNKEALPRCGILTLRDVLALQHENVPKISEKDPLRAEVLVRLYRRVNALLAPPSQVPNLDVNNIIQNMQLGGVGVGAGQMELDATGAADHGVGPDDAENIHRMIDNAAAAAGLDSSGTGLDTSIDDVLNAADMAVGNPEFLDLDMEGMF
Length1007
PositionTail
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.008
Instability index43.91
Isoelectric point4.96
Molecular weight110956.95
Publications
PubMed=16372009

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.27|      14|      25|     267|     280|       1
---------------------------------------------------------------------------
  267-  280 (26.59/14.94)	VMDGPVINSRAGLY
  293-  306 (26.68/15.00)	VDDGMLINYLANRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.22|      25|      27|     854|     878|       2
---------------------------------------------------------------------------
  854-  878 (45.12/33.78)	HQPVDPNKEALP.RCGILT..LRDVLAL
  880-  907 (34.10/23.53)	HENVPKISEKDPlRAEVLVrlYRRVNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.55|      14|      27|     650|     663|       3
---------------------------------------------------------------------------
  650-  663 (25.46/15.79)	FEYLLEPFL....LPSLI
  674-  691 (21.09/11.68)	WEMELDPSIplkvLHSLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.70|      23|      27|     436|     461|       4
---------------------------------------------------------------------------
  436-  461 (31.84/29.14)	NKDELVSQINanpERAEQLINEIESM
  464-  486 (39.86/26.41)	NAGAIIGAIT...EVMHNLCNQKETM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.72|      23|      27|     953|     975|       5
---------------------------------------------------------------------------
  953-  975 (39.37/23.90)	DDAENIHRMIDNAAAAAGLDSSG
  983- 1005 (39.35/23.88)	DDVLNAADMAVGNPEFLDLDMEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.03|      13|      18|     744|     757|       7
---------------------------------------------------------------------------
  744-  757 (17.86/14.43)	SFQLVGSShRSELE
  764-  776 (23.16/13.07)	SGGLLGSI.RSTFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.96|      14|      20|     611|     624|      10
---------------------------------------------------------------------------
  611-  624 (26.21/17.39)	ETMSAC..SPQEFYLL
  631-  646 (19.75/11.22)	QSLEACetGKLEFDTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31732 with Med5 domain of Kingdom Fungi
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