<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31730

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMVRAQETVYDLITKCSVRRVPPKQFVNFYNEFFNERYDSVLENGNPAGESRPTAPVYEEVAQDLVRILNDSRVNLVADYVLEIVLINLNVDLLRLFLPKLHHVRNVMLLVHLFSRATAFISGLDNKLLAEQISDTVYTDVTPAVLSFNMQAIDDQLVIVLAKFLHAVLRLPEGQQKMGSVPTKQKAATLLQRLSTIDRLLYKRFIADLDGKLRLSGAPADMSFPLPPSNMPSPSVTSPKYETSSVGVMKRSTSMSNEAKYQDIKLARYYKNLWLNNKIHYCTVSDPLFLEKYDSILELATGGGLSADRPVKAKIADLVETAFTCFAQFVSNKLYHQSNSNFSLLERKWTVFVTKQLPLIIKSSIPDKTDIVLRTLENIDDKVIKAIKSYNTEKEEVKNRTEDLFDDYPVNSLDIRHEFLKNLIMMGLQPPTVLNEYLREDQMVDLKSLVTSEHLIIDNSQGVRETILNVRNFITKSIESLEFENLFDDGNQLLVTNDHGIIQIAHNLETISPTKQLEIANILYDLLSAAIESLDHKTISKVLTILTLNVGHLLTNIFCLTGYEKFARAVIRFIDVIWESNKSKSNDMVSDDSEFENINSAMAYTLSLCFIIHVVDIYGVNVEALVENPSKSTVLRFLSKLGEIPEVFVAPEGDLESSKTLLQQWLRELFVKNLISDNLMKSADVKVMGFMIPFIFKQTLLNVEYGIISDISSFVNGFEYFLQPFLSVGLINIVFWLEKYLLALKTTESFPKINGALFDILGAIIAPKSIGSDAKAIHSVVLKLKCVGLLKELKSFQVPSESNYGIYSSQTRQDPRLEALISKLELIAQSSALYDVDPRIISAVNNNYSQKHISYNKVVLTSDIPINKIMTNQINSFWNLHSSTYYNFDYLLELIDLVTPFKFVQDVFQTLKYKVTAYGVPGSATKPSSAALDQVLGYVFYFMVLRDIKCPEEKSLLLEYLDSGRFPSSISATVLTSDPTTISGMPPVSMPYDVKSEQDAMEGVDEDFDMLFGESFSGLPDDVQKSADMKPDTGIKEDDSEKSSYVSAARLTESFGVIFSKMKKDKLEAYQAGQISEERYQCFMGLYDKYVQTLRHSVI
Length1098
PositionTail
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.09
Grand average of hydropathy-0.044
Instability index39.73
Isoelectric point5.33
Molecular weight123997.09
Publications
PubMed=15001715
PubMed=23749448

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
histone H3 acetylation	GO:0043966	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
transcription by RNA polymerase II	GO:0006366	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31730
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     572.69|     149|     152|     524|     674|       1
---------------------------------------------------------------------------
  524-  671 (221.60/157.78)	....DLL..SAAIESLDHKTISKVLTILTLNVGH.LLTNIFC.LTGYEKFARAV..IRFIDVI.WESNKSKSNDMVSDDSEFENINSAMAYTLsLCFIIHV.......VDIYGVNVEALvENPSKSTVLRFLSKLGEIPEV..FVAP.EGD..LESSKTLLQQWLRELFVK
  672-  822 (171.08/113.38)	NLIsDNLmkSADVKVMGF.MIPFIFKQTLLNVEYgIISDISSfVNGFEYFLQPFlsVGLINIVfWLEKYLLA..LKTTES.FPKINGAL.FDI.LGAIIAP.......KSI.GSDAKAI.....HSVVLK.LKCVGLLKELksFQVPsESNygIYSSQTRQDPRLEALISK
  824-  960 (180.00/119.73)	ELI....aqSSALYDVDPRIISAVNNNYSQK..H.ISYNKVV.LTSDIPINKIM..TNQINSF.WNLHSSTYYNF...DYLLELIDLVTPFK....FVQDVfqtlkykVTAYGVPGSA..TKPSSAALDQV...LGYVFYF..MVLR.DIK..CPEEKSLLLEYL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.80|      34|     252|      30|      65|       2
---------------------------------------------------------------------------
   30-   65 (53.63/43.75)	NEFFNERYDSVLENGNPAGESrPTAPVYEEVAqDLV
  285-  318 (59.17/38.38)	DPLFLEKYDSILELATGGGLS.ADRPVKAKIA.DLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.58|      12|      17|     417|     428|       3
---------------------------------------------------------------------------
  417-  428 (20.91/11.87)	EFLKNLIMMGLQ
  435-  446 (20.67/11.66)	EYLREDQMVDLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.24|      18|      43|     448|     466|       4
---------------------------------------------------------------------------
  448-  466 (26.56/27.61)	LVTSEHLIIDNSQGVrETI
  493-  510 (29.68/24.11)	LVTNDHGIIQIAHNL.ETI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.05|      22|      74|      74|      95|       6
---------------------------------------------------------------------------
   74-   95 (32.53/21.09)	NLVA.DYVLEIVLINLNVDLLRL
  126-  147 (31.33/20.03)	KLLA.EQISDTVYTDVTPAVLSF
  148-  170 (30.20/19.04)	NMQAiDDQLVIVLAKFLHAVLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.78|      27|     806|     199|     277|       7
---------------------------------------------------------------------------
  203-  231 (41.28/104.23)	RFIADLDGKLrLSGAPADMSfPLPPSNMP
  964-  990 (49.50/ 8.81)	RFPSSISATV.LTSDPTTIS.GMPPVSMP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31730 with Med5 domain of Kingdom Fungi
Unable to open file!