<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31720

Description Isoform 2 of Mediator of RNA polymerase II transcription subunit 4
SequenceMAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD
Length224
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.03
Grand average of hydropathy-0.621
Instability index50.47
Isoelectric point5.02
Molecular weight29745.10
Publications
PubMed=10235266
PubMed=10882111
PubMed=11042152
PubMed=14702039
PubMed=15057823
PubMed=15489334
PubMed=10235267
PubMed=15175163
PubMed=15989967
PubMed=19369195
PubMed=19690332
PubMed=21269460
PubMed=22814378

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
membrane	GO:0016020	HDA:UniProtKB
nucleoplasm	GO:0005654	IDA:HPA
nucleus	GO:0005634	IDA:UniProtKB

GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	NAS:UniProtKB
thyroid hormone receptor binding	GO:0046966	IDA:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
transcription coregulator activity	GO:0003712	IDA:UniProtKB
vitamin D receptor binding	GO:0042809	NAS:UniProtKB

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
transcription by RNA polymerase II	GO:0006366	IDA:UniProtKB









Interaction





Binary Interactions
[Q9NPJ6<-->A2BDD9: AMOT]	NbExp=3	EBI-394607,EBI-17286414
[Q9NPJ6<-->Q4VCS5-2: AMOT]	NbExp=3	EBI-394607,EBI-3891843
[Q9NPJ6<-->Q8TAB5: C1orf216]	NbExp=3	EBI-394607,EBI-747505
[Q9NPJ6<-->Q8IYE0-2: CCDC146]	NbExp=3	EBI-394607,EBI-10247802
[Q9NPJ6<-->Q8TD31-3: CCHCR1]	NbExp=6	EBI-394607,EBI-10175300
[Q9NPJ6<-->Q8WYA6: CTNNBL1]	NbExp=3	EBI-394607,EBI-748128
[Q9NPJ6<-->Q8NE31: FAM13C]	NbExp=3	EBI-394607,EBI-751248
[Q9NPJ6<-->Q96NE9: FRMD6]	NbExp=3	EBI-394607,EBI-741729
[Q9NPJ6<-->O95954: FTCD]	NbExp=3	EBI-394607,EBI-10192648
[Q9NPJ6<-->Q96CN9: GCC1]	NbExp=3	EBI-394607,EBI-746252
[Q9NPJ6<-->Q96CS2: HAUS1]	NbExp=4	EBI-394607,EBI-2514791
[Q9NPJ6<-->O14964: HGS]	NbExp=3	EBI-394607,EBI-740220
[Q9NPJ6<-->Q8IY31: IFT20]	NbExp=4	EBI-394607,EBI-744203
[Q9NPJ6<-->Q96PC2: IP6K3]	NbExp=3	EBI-394607,EBI-10990676
[Q9NPJ6<-->Q9BVG8: KIFC3]	NbExp=3	EBI-394607,EBI-2125614
[Q9NPJ6<-->Q9BVG8-5: KIFC3]	NbExp=3	EBI-394607,EBI-14069005
[Q9NPJ6<-->Q32MZ4-4: LRRFIP1]	NbExp=3	EBI-394607,EBI-10240044
[Q9NPJ6<-->Q8N8X9: MAB21L3]	NbExp=3	EBI-394607,EBI-10268010
[Q9NPJ6<-->Q96EZ8: MCRS1]	NbExp=4	EBI-394607,EBI-348259
[Q9NPJ6<-->Q93074: MED12]	NbExp=8	EBI-394607,EBI-394357
[Q9NPJ6<-->Q13503: MED21]	NbExp=5	EBI-394607,EBI-394678
[Q9NPJ6<-->O95402: MED26]	NbExp=11	EBI-394607,EBI-394392
[Q9NPJ6<-->Q9NWA0: MED9]	NbExp=12	EBI-394607,EBI-394653
[Q9NPJ6<-->O14777: NDC80]	NbExp=4	EBI-394607,EBI-715849
[Q9NPJ6<-->O43482: OIP5]	NbExp=3	EBI-394607,EBI-536879
[Q9NPJ6<-->O00560: SDCBP]	NbExp=3	EBI-394607,EBI-727004
[Q9NPJ6<-->Q96ES7: SGF29]	NbExp=3	EBI-394607,EBI-743117
[Q9NPJ6<-->Q96GM5: SMARCD1]	NbExp=6	EBI-394607,EBI-358489
[Q9NPJ6<-->Q969G3: SMARCE1]	NbExp=3	EBI-394607,EBI-455078
[Q9NPJ6<-->Q99909: SSX3]	NbExp=6	EBI-394607,EBI-10295431
[Q9NPJ6<-->Q6PIF2: SYCE2]	NbExp=3	EBI-394607,EBI-11958386
[Q9NPJ6<-->Q08117: TLE5]	NbExp=3	EBI-394607,EBI-717810
[Q9NPJ6<-->O95379: TNFAIP8]	NbExp=7	EBI-394607,EBI-1049336
[Q9NPJ6<-->Q8WVP5: TNFAIP8L1]	NbExp=3	EBI-394607,EBI-752102
[Q9NPJ6<-->P40222: TXLNA]	NbExp=8	EBI-394607,EBI-359793
[Q9NPJ6<-->Q8N3L3: TXLNB]	NbExp=4	EBI-394607,EBI-6116822
[Q9NPJ6<-->Q8N6Y0: USHBP1]	NbExp=6	EBI-394607,EBI-739895












Repeat regions





Repeats

>MDP31720
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.57|      27|      28|      55|      81|       1
---------------------------------------------------------------------------
   29-   49 (30.78/20.44)	RLLSALE...D...LEVL..SR..ELIEMLA
   55-   81 (47.46/35.46)	KLLQAGE...ENQVLELLI.HRDGEFQELMK
   84-  112 (26.32/16.43)	..LNQGKihhEMQVLEKEVeKRDSDIQQLQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.07|      23|      23|     216|     238|       2
---------------------------------------------------------------------------
  216-  238 (44.66/26.20)	LAPQYPWQSNDMSMNMLPPNHSS
  242-  264 (39.42/22.41)	LEPPGHNKENEDDVEIMSTDSSS
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31720 with Med4 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAG
2) WQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD
166
222
210
270










Molecular Recognition Features






MoRF SequenceStartStop




NANANA