<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31714

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMETNLDGCFERVEKTLGSMIDSLAKNNPSQKLAEELLAAEAELSKSLKLLETHQNNNARLQQLRQETSLHDTQLKDIMSSLWNMRRELKAVPTTSNPPPGPKHQFTTSELLAYARRISRNTLPLPGVTNGVDMTPTQFSASLTEPEDSFRLQFQPTQTQTPTNSFNLSFNGTVSTPIGLSAPTPTTTNDTQPSTQLPPSQQPPPKTAPADDKLPAHLKPAVNPLHDAAFHPWPTEGQIRTGALAALQRLVDAGIEPRGYDPAEQERRRVAEEKARREAEERARLEREEAERKGREERERMAREREAARLRNAGGADGDGERRESVAVARPKPKQFTFLGADDDEDDEDEDD
Length351
PositionMiddle
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.04
Grand average of hydropathy-0.974
Instability index47.23
Isoelectric point5.21
Molecular weight39081.79
Publications
PubMed=25720678

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31714
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.32|      21|      23|     263|     284|       1
---------------------------------------------------------------------------
  263-  284 (31.21/18.61)	EQERRRVAEEKAR..REaEERARL
  287-  309 (31.11/14.59)	EEAERKGREERERmaRE.REAARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.89|      43|      45|     118|     161|       2
---------------------------------------------------------------------------
  118-  161 (70.65/35.44)	SRNtLPLPG.VTNGVDMT.PTQFSASLTEPEDSFRLQFQPTQTQTP
  164-  208 (67.24/30.23)	SFN.LSFNGtVSTPIGLSaPTPTTTNDTQPSTQLPPSQQPPPKTAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.86|      12|      27|     220|     231|       4
---------------------------------------------------------------------------
  220-  231 (23.17/12.93)	AVNPLHDAAFHP
  245-  256 (20.69/10.93)	ALQRLVDAGIEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.29|      21|      28|      14|      35|       5
---------------------------------------------------------------------------
   14-   35 (29.78/21.17)	KTLgSMIDSLAKNNPS.QKLAEE
   45-   66 (30.51/16.77)	KSL.KLLETHQNNNARlQQLRQE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31714 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TLPLPGVTNGVDMTPTQFSASLTEPEDSFRLQFQPTQTQTPTNSFNLSFNGTVSTPIGLSAPTPTTTNDTQPSTQLPPSQQPPPKTAPADDKLPAHLKPAVNPLHDAAFHPWPTEGQIRTGALAALQRLVDAGIEPRGYDPAEQERRRVAEEKARREAEERARLEREEAERKGREERERMAREREAARLRNAGGADGDGERRESVAVARPKPKQFTFLGADDDEDDEDEDD
121
351










Molecular Recognition Features






MoRF SequenceStartStop




1) ERMAREREAARLRNAGGADGDGERRESVAVARPKPKQFTFLGADDDEDDED
298
348