<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31713
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSLVAESNSGTISEQELDKVQLYSDLCLYEEALTKLVDSVDNFKPQLEIGKQLIEADKKLYSTLDLLPQYDSVFTRLRTLDDEISKVDQQTKNILSILNECHDDLNALPLLEEVEFEKKMILKQREKIKSNVLLEYATKLAKFTKIPPTFDKGTIGPNNFIWPAEDALRKGMLAMASLHGKELTKLPGQEDGEEDGSTANEDKNIVKDAEGAEGEIRQDDKKEDDSFVFGANANDAEGDEDKNAGEDEDEAMDSDLDLFNPDEF |
Length | 264 |
Position | Middle |
Organism | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Nakaseomyces>
Nakaseomyces/Candida clade.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.675 |
Instability index | 41.21 |
Isoelectric point | 4.28 |
Molecular weight | 29617.55 |
Publications | PubMed=15229592
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
transcription by RNA polymerase II GO:0006366 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP31713
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 106.64| 31| 31| 64| 94| 2
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38- 70 (40.89/24.33) DSVdnFKPQLEIGK.QLIE..ADKKLYSTLDLLPQY
71- 101 (48.12/29.80) DSV..FTRLRTLDD.EISK..VDQQTKNILSILNEC
102- 128 (17.63/ 6.71) HDD..LNALPLLEEvEFEKkmILKQREKI.......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.74| 12| 25| 163| 174| 4
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163- 174 (21.03/11.18) PA.EDALRKGMLA
187- 199 (17.71/ 8.44) PGqEDGEEDGSTA
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