<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31705
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSSYHLSTKERLLAIVDDIEIISKELIENTIAPKHQKMSSADHGQLVELLVSKDKELKATLQLAAEQAGIEKKMDGLREQVKEQDEEINQLQKQLKEAEHILATSIFQGRQKLSSINKAVKRPVSSEELIKFAHRISASNAICAPLTWQQGDLRRPYPTDIEMRLGFLGKSDLNINGHNAPNQNNLNEMQRNAAGAGAGSGVADIPASAQNQFAWHPSGELHMTMGAGAGSVSLDTRSHKDASQDDVEVMSTDSSSSSSSDSQ |
Length | 263 |
Position | Middle |
Organism | Aedes aegypti (Yellowfever mosquito) (Culex aegypti) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae>
Culicinae> Aedini> Aedes> Stegomyia.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.575 |
Instability index | 58.09 |
Isoelectric point | 5.61 |
Molecular weight | 28680.74 |
Publications | PubMed=17510324
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31705
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 100.38| 35| 38| 54| 91| 3
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54- 88 (54.85/42.53) DKELKATLQ.LAAEQAGIEKKMDGLREQVKE..QDEEI
92- 129 (45.52/26.25) QKQLKEAEHiLATSIFQGRQKLSSINKAVKRpvSSEEL
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