<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31702

Description Mediator of RNA polymerase II transcription subunit 3
SequenceMATKQEEQANLSDVLTPSMSLTELEMKFADETDGKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEERYANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKNFQVLENLASYNHRGKAGASISNSTPTPAAATPTTAPTPGAGTKKAAKTAPTPTATATIGTPSNNAPTPATTATTPGTQAKKPRKPRQTKKQQQAAAAAAAVAQAQAQAQAQAQNQNQNNMQNKNISNPGMNSNMGTPVMGNPNMKQMQSPIPANAMNNMNVPHNGAMRPSVPNGNMGNPSMGNLNMNAPNMGNPNMNNPNMNNPNAMMSPMAGQGQLNQMFPMQNHNQNGQFMGQQSPGPNIGQMQFPPNNGNMNGMPGTSDMNLGMNPSMNMNMGMNLNQITPANILSMNTKGKDDQMQNIGMDQNQNQNQSQNQSQNQNQSMNMNMNNDSNNPKSAYDLVDFNSLDLSSLNMDFL
Length481
PositionTail
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Nakaseomyces> Nakaseomyces/Candida clade.
Aromaticity0.04
Grand average of hydropathy-0.874
Instability index38.74
Isoelectric point8.84
Molecular weight52083.78
Publications
PubMed=15229592

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31702
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.97|      20|      22|     293|     313|       1
---------------------------------------------------------------------------
  251-  269 (29.69/ 8.12)	NP.........gmNSNMGTPVMGNPNMK
  285-  311 (30.56/12.78)	VPhngamrPSV.pNGNMGNPSMGNLNMN
  391-  406 (27.73/ 6.95)	MN......PSM..NMNMG...M.NLNQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.13|      21|      22|     155|     176|       2
---------------------------------------------------------------------------
  155-  175 (39.30/24.10)	TP.TTAPTPGAGTKKAAKTAPT
  178-  191 (23.90/ 6.72)	AT.ATIGTPS...NN....APT
  192-  212 (27.93/ 9.79)	.PaTTATTPGTQAKKPRKPRQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.71|      21|      21|     347|     367|       3
---------------------------------------------------------------------------
  315-  339 (31.63/ 9.03)	MGNPNMNNPNMnnpnAMMSPMA...GQG
  347-  367 (44.50/16.44)	MQNHNQNGQFM....GQQSPGP...NIG
  369-  390 (31.58/ 9.01)	MQFPPNNGNMN....GM..PGTsdmNLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.26|      32|      40|      45|      83|       4
---------------------------------------------------------------------------
   45-   83 (44.18/45.63)	KKAEDgilplRLQ..FNDFTQI...MSSLDEerYANVSKQEKFQ
   90-  126 (45.08/28.00)	LGLTE.....RLQelSNDFEELqplFATVGE..YSKTYKNKNFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.55|      16|      17|     424|     439|       5
---------------------------------------------------------------------------
  231-  246 (29.11/10.79)	QAQAQAQNQNQNNMQN
  424-  439 (33.18/13.39)	QNIGMDQNQNQNQSQN
  444-  458 (29.26/10.88)	QNQSMNMNMN.NDSNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31702 with Med3 domain of Kingdom Fungi
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