<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31688

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK
Length131
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.15
Grand average of hydropathy-0.644
Instability index31.34
Isoelectric point8.72
Molecular weight15804.95
Publications
PubMed=10810093
PubMed=14702039
PubMed=15489334
PubMed=10024883
PubMed=11867769
PubMed=12584197
PubMed=15175163
PubMed=15989967
PubMed=18691976
PubMed=21269460
PubMed=22814378

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	TAS:Reactome
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process
limb development	GO:0060173	IEA:Ensembl
negative regulation of fibroblast proliferation	GO:0048147	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome









Interaction





Binary Interactions
[Q9Y3C7<-->O95257: GADD45G]	NbExp=2	EBI-394707,EBI-448202
[Q9Y3C7<-->P42858: HTT]	NbExp=9	EBI-394707,EBI-466029
[Q9Y3C7<-->O43513: MED7]	NbExp=3	EBI-394707,EBI-394632
[Q9Y3C7<-->Q96HR8: NAF1]	NbExp=3	EBI-394707,EBI-2515597












Repeat regions





Repeats

>MDP31688
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.11|      35|      44|      22|      65|       1
---------------------------------------------------------------------------
   22-   63 (48.15/50.86)	LEFVQCLanpNYLNFLaQRGYFKdKAFVN.....YL..KYLLYWKdpEY
   67-  108 (57.96/29.78)	LKYPQCL...HMLELL.QYEHFR.KELVNaqcakFIdeQQILHWQ..HY
---------------------------------------------------------------------------











Associated diseases
Disease
osteosarcoma	PMID:24969180



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31688 with Med31 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA