<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31688

Description Mediator of RNA polymerase II transcription subunit 31
SequenceMAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK
Length131
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.15
Grand average of hydropathy-0.644
Instability index31.34
Isoelectric point8.72
Molecular weight15804.95
Publications
PubMed=10810093
PubMed=14702039
PubMed=15489334
PubMed=10024883
PubMed=11867769
PubMed=12584197
PubMed=15175163
PubMed=15989967
PubMed=18691976
PubMed=21269460
PubMed=22814378

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	TAS:Reactome
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process
limb development	GO:0060173	IEA:Ensembl
negative regulation of fibroblast proliferation	GO:0048147	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31688
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.11|      35|      44|      22|      65|       1
---------------------------------------------------------------------------
   22-   63 (48.15/50.86)	LEFVQCLanpNYLNFLaQRGYFKdKAFVN.....YL..KYLLYWKdpEY
   67-  108 (57.96/29.78)	LKYPQCL...HMLELL.QYEHFR.KELVNaqcakFIdeQQILHWQ..HY
---------------------------------------------------------------------------











Associated diseases
Disease
osteosarcoma	PMID:24969180



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31688 with Med31 domain of Kingdom Metazoa
Unable to open file!