<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31667

Description Isoform 2 of Mediator of RNA polymerase II transcription subunit 30
SequenceMSTPPLAASGMAPGPFAGPQAQQAAREVNTASLCRIGQETVQDIVYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDNLRQLSVLFRKLRLVYDKCNENCGGMDPIPVEQLIPYVEEDGSKNDDRAGPPRFASEERREIAEVNKKLKQKNQQLKQIMDQLRNLIWDINAMLAMRN
Length143
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.06
Grand average of hydropathy-0.608
Instability index44.15
Isoelectric point8.45
Molecular weight20277.02
Publications
PubMed=11909976
PubMed=16421571
PubMed=15489334
PubMed=12584197
PubMed=15175163
PubMed=15989967
PubMed=16595664
PubMed=18691976
PubMed=19413330
PubMed=19369195
PubMed=21406692
PubMed=22814378
PubMed=23186163

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000269	PubMed:11909976
ECO:0000269	PubMed:16595664
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	IDA:UniProtKB
ubiquitin ligase complex	GO:0000151	IEA:Ensembl
GO - Biological Function
nuclear receptor coactivator activity	GO:0030374	NAS:UniProtKB
thyroid hormone receptor binding	GO:0046966	IDA:UniProtKB
transcription coactivator activity	GO:0003713	IDA:UniProtKB
transcription coregulator activity	GO:0003712	IDA:UniProtKB
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl
vitamin D receptor binding	GO:0042809	NAS:UniProtKB
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions
[Q96HR3<-->Q8NF50-2: DOCK8]	NbExp=3	EBI-394659,EBI-10174653
[Q96HR3<-->O14964: HGS]	NbExp=5	EBI-394659,EBI-740220
[Q96HR3<-->P42858: HTT]	NbExp=3	EBI-394659,EBI-466029
[Q96HR3<-->Q8IY31-3: IFT20]	NbExp=3	EBI-394659,EBI-9091197
[Q96HR3<-->P60411: KRTAP10-9]	NbExp=3	EBI-394659,EBI-10172052
[Q96HR3<-->Q9H204: MED28]	NbExp=6	EBI-394659,EBI-514199
[Q96HR3<-->Q9ULW6: NAP1L2]	NbExp=3	EBI-394659,EBI-3911716
[Q96HR3<-->Q9Y5B8: NME7]	NbExp=5	EBI-394659,EBI-744782

Repeat regions

Repeats

>MDP31667
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.90|      21|      69|      77|      97|       1
---------------------------------------------------------------------------
   77-   97 (34.99/17.58)	KLQDNLRQLSVLFRKLR.LVYD
  148-  169 (32.90/16.25)	KLKQKNQQLKQIMDQLRnLIWD
---------------------------------------------------------------------------

Associated diseases

Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31667 with Med30 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA