<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31653

Description Mediator of RNA polymerase II transcription subunit 29
SequenceMAASQQQASAASSAAGVSGPSSAGGPGPQQQPQPPAQLVGPAQSGLLQQQQQDFDPVQRYKMLIPQLKESLQTLMKVAAQNLIQNTNIDNGQKSSDGPIQRFDKCLEEFYALCDQLELCLRLAHECLSQSCDSAKHSPTLVPTATKPDAVQPDSLPYPQYLAVIKAQISCAKDIHTALLDCANKVTGKTPAPPAGPGGTL
Length200
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.04
Grand average of hydropathy-0.366
Instability index69.14
Isoelectric point5.86
Molecular weight21072.64
Publications
PubMed=15555573
PubMed=14702039
PubMed=17974005
PubMed=15057824
PubMed=15489334
PubMed=14576168
PubMed=14638676
PubMed=15175163
PubMed=15989967
PubMed=19413330

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000269	PubMed:15555573
GO - Cellular Component
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	IDA:HPA
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
transcription factor binding	GO:0008134	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions
[Q9NX70<-->Q9NYB9-2: ABI2]	NbExp=3	EBI-394656,EBI-11096309
[Q9NX70<-->Q9P2A4: ABI3]	NbExp=3	EBI-394656,EBI-742038
[Q9NX70<-->O75934: BCAS2]	NbExp=3	EBI-394656,EBI-1050106
[Q9NX70<-->Q14232: EIF2B1]	NbExp=3	EBI-394656,EBI-491065
[Q9NX70<-->Q9BUE0: MED18]	NbExp=6	EBI-394656,EBI-394640
[Q9NX70<-->A0JLT2: MED19]	NbExp=8	EBI-394656,EBI-394430
[Q9NX70<-->Q9H944: MED20]	NbExp=6	EBI-394656,EBI-394644
[Q9NX70<-->Q15528: MED22]	NbExp=4	EBI-394656,EBI-394687
[Q9NX70<-->Q9H204: MED28]	NbExp=3	EBI-394656,EBI-514199
[Q9NX70<-->O75586: MED6]	NbExp=3	EBI-394656,EBI-394624
[Q9NX70<-->Q9H7Z3: NRDE2]	NbExp=3	EBI-394656,EBI-1042642
[Q9NX70<-->A1L4H1: SSC5D]	NbExp=3	EBI-394656,EBI-10172867
[Q9NX70<-->Q9D8C6: Med11]	Xeno	NbExp=2,
[Q9NX70<-->Q9R0X0: Med20]	Xeno	NbExp=2,
[Q9NX70<-->Q9CQI9: Med30]	Xeno	NbExp=2,
[Q9NX70<-->Q9D7W5: Med8]	Xeno	NbExp=2,

Repeat regions

Repeats

>MDP31653
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.26|      14|     167|      14|      27|       1
---------------------------------------------------------------------------
   14-   27 (26.59/11.46)	AAGVSG..PSSAGGPG
  182-  197 (22.67/ 8.86)	ANKVTGktPAPPAGPG
---------------------------------------------------------------------------

Associated diseases

Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31653 with Med29 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAASQQQASAASSAAGVSGPSSAGGPGPQQQPQPPAQLVGPAQSGLLQQQQ
1
51










Molecular Recognition Features






MoRF SequenceStartStop




1) MAASQQQASAASSAA
1
15