<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31652
Description |
Mediator of RNA polymerase II transcription subunit 29 |
Sequence | MNPNMNMMQMSGPPMMQVSPMMQSSPQPMMPTGPPGPVPMQQQHQQQQQQQQQQQQQQQQQAEKLDNISRVKSLLGPLRESMFLTIRSSAFTLQQNNLADNLKRDTGGHGHVPRFDKHLEDFYACCDQMELHLKTAIQCMQQLTSSQHYLPGAVTAMRMENFMQDNPAGPIPYPTYLNTVRVHVQSAKDIHDTLISAAQNISQAD |
Length | 205 |
Position | Tail |
Organism | Drosophila virilis (Fruit fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea>
Drosophilidae> Drosophila.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.734 |
Instability index | 67.13 |
Isoelectric point | 6.42 |
Molecular weight | 23200.18 |
Publications | PubMed=15645316
PubMed=17994087
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 ISS:UniProtKB
|
GO - Biological Function | transcription coregulator activity GO:0003712 ISS:UniProtKB
transcription factor binding GO:0008134 IEA:EnsemblMetazoa
|
GO - Biological Process | genital disc sexually dimorphic development GO:0035263 IEA:EnsemblMetazoa
imaginal disc-derived female genitalia morphogenesis GO:0048804 IEA:EnsemblMetazoa
negative regulation of cell death GO:0060548 IEA:EnsemblMetazoa
regulation of transcription by RNA polymerase II GO:0006357 ISS:UniProtKB
sex determination GO:0007530 IEA:EnsemblMetazoa
|
Interaction
Repeat regions
Repeats |
>MDP31652
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 55.12| 14| 18| 12| 27| 1
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12- 27 (24.50/16.41) GPPmmQVSPMMQSSPQ
33- 46 (30.62/14.14) GPP..GPVPMQQQHQQ
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