<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31640

Description Mediator of RNA polymerase II transcription subunit 28
SequenceMAAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQASANIPAPLKPT
Length178
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.05
Grand average of hydropathy-0.452
Instability index61.27
Isoelectric point5.39
Molecular weight19519.94
Publications
PubMed=11779215
PubMed=15489334
PubMed=15175163
PubMed=15467741
PubMed=15989967
PubMed=21269460

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. 
ECO:0000269	PubMed:15467741
GO - Cellular Component
cortical actin cytoskeleton	GO:0030864	IEA:Ensembl
mediator complex	GO:0016592	IBA:GO_Central
membrane	GO:0016020	IEA:UniProtKB-SubCell
nucleoplasm	GO:0005654	IDA:HPA
GO - Biological Function
actin binding	GO:0003779	IEA:UniProtKB-KW
GO - Biological Process
negative regulation of smooth muscle cell differentiation	GO:0051151	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions
[Q9H204<-->Q8NA61: CBY2]	NbExp=3	EBI-514199,EBI-741724
[Q9H204<-->Q8NA61-2: CBY2]	NbExp=3	EBI-514199,EBI-11524851
[Q9H204<-->P26378-2: ELAVL4]	NbExp=3	EBI-514199,EBI-21603100
[Q9H204<-->P06241: FYN]	NbExp=6	EBI-514199,EBI-515315
[Q9H204<-->P62993: GRB2]	NbExp=3	EBI-514199,EBI-401755
[Q9H204<-->P42858: HTT]	NbExp=9	EBI-514199,EBI-466029
[Q9H204<-->P06239: LCK]	NbExp=4	EBI-514199,EBI-1348
[Q9H204<-->Q5TCQ9: MAGI3]	NbExp=2	EBI-514199,EBI-310506
[Q9H204<-->Q9NVC6: MED17]	NbExp=2	EBI-514199,EBI-394562
[Q9H204<-->Q15528: MED22]	NbExp=2	EBI-514199,EBI-394687
[Q9H204<-->Q9NX70: MED29]	NbExp=3	EBI-514199,EBI-394656
[Q9H204<-->Q96HR3: MED30]	NbExp=6	EBI-514199,EBI-394659
[Q9H204<-->Q5JXC2: MIIP]	NbExp=3	EBI-514199,EBI-2801965
[Q9H204<-->Q92597: NDRG1]	NbExp=3	EBI-514199,EBI-716486
[Q9H204<-->P35240: NF2]	NbExp=4	EBI-514199,EBI-1014472
[Q9H204<-->P35240-1: NF2]	NbExp=2	EBI-514199,EBI-1014500
[Q9H204<-->Q96LA8: PRMT6]	NbExp=2	EBI-514199,EBI-912440
[Q9H204<-->Q9UHX1: PUF60]	NbExp=6	EBI-514199,EBI-1053259
[Q9H204<-->P12931: SRC]	NbExp=3	EBI-514199,EBI-621482
[Q9H204<-->P51687: SUOX]	NbExp=3	EBI-514199,EBI-3921347
[Q9H204<-->Q8WWU5-7: TCP11]	NbExp=3	EBI-514199,EBI-17721485
[Q9H204<-->P07947: YES1]	NbExp=2	EBI-514199,EBI-515331
[Q9H204<-->Q9D8C6: Med11]	Xeno	NbExp=2,
[Q9H204<-->Q9CQI9: Med30]	Xeno	NbExp=2,
[Q9H204<-->Q9D7W5: Med8]	Xeno	NbExp=2,
[Q9H204<-->P03255]	Xeno	NbExp=2,

Repeat regions

Repeats

>MDP31640
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.84|      15|      16|     117|     132|       2
---------------------------------------------------------------------------
  117-  132 (21.37/22.81)	ELRNELQ.RKDALVQkH
  135-  150 (24.48/19.69)	KLRHWQQvLEDINVQ.H
---------------------------------------------------------------------------

Associated diseases

Disease
breast cancer	PMID:25723281


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP31640 with Med28 domain of Kingdom Metazoa



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTL
2
44










Molecular Recognition Features






MoRF SequenceStartStop




NANANA