<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31629

Description Isoform 2 of Mediator of RNA polymerase II transcription subunit 27
SequenceMADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ
Length275
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.08
Grand average of hydropathy-0.322
Instability index40.43
Isoelectric point9.37
Molecular weight35431.35
Publications
PubMed=8889548
PubMed=15164053
PubMed=15489334
PubMed=9989412
PubMed=10882111
PubMed=15175163
PubMed=15989967
PubMed=21269460
PubMed=23186163
PubMed=24129315

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000269	PubMed:10882111
ECO:0000269	PubMed:9989412
GO - Cellular Component
cytosol	GO:0005829	IDA:HPA
mediator complex	GO:0016592	IEA:InterPro
nucleolus	GO:0005730	IDA:HPA
nucleoplasm	GO:0005654	IDA:HPA
nucleus	GO:0005634	IDA:UniProtKB
transcription regulator complex	GO:0005667	IDA:MGI
GO - Biological Function
transcription coactivator activity	GO:0003713	IDA:UniProtKB
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IDA:MGI
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
transcription initiation from RNA polymerase II promoter	GO:0006367	TAS:ProtInc

Interaction

Binary Interactions
[Q6P2C8<-->Q9NVC6: MED17]	NbExp=3	EBI-394603,EBI-394562
[Q6P2C8<-->Q15528: MED22]	NbExp=3	EBI-394603,EBI-394687
[Q6P2C8<-->O75586: MED6]	NbExp=2	EBI-394603,EBI-394624
[Q6P2C8<-->Q9R0X0: Med20]	Xeno	NbExp=2,
[Q6P2C8<-->Q9CQI9: Med30]	Xeno	NbExp=2,
[Q6P2C8<-->Q9D7W5: Med8]	Xeno	NbExp=2,

Repeat regions

Repeats

>MDP31629
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.06|      32|      32|     147|     178|       1
---------------------------------------------------------------------------
  147-  178 (55.24/38.53)	RPKAQPTTLVLPPQYVDDVISRIDRMFPEMSI
  182-  213 (48.82/33.30)	RPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTI
---------------------------------------------------------------------------

Associated diseases

Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31629 with Med27 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA