<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31627

Description Putative mediator of RNA polymerase II transcription subunit 27
SequenceMQVQQPQQIQQQHLQQQQAQQHQQQQVQQHQQQQQQQQQQQQIYQQIVNQPVNNVHQLPSLQQQQLLEQYDELLKQVSLIRSNVSDFFNSFIEDAKQQQTIVNKEEMKQKLKKSMDLVLGSISSIDKVSKRISSYSFQIASSNFSTQEASWAYSTGIYDNRNIKVQLEIRNENYWRSQTSYKSSLASSNLENKLKDLFPIIFQEDEESSSLSKKRKQISSLTSNSLSTTTITTTTTPSPLFKLPSTPPTLLLSGTISPFYDYFAQIERVIHSIRQESALEIFEIQKQSSGAPKGLFVECPDVFKCLICFGIPNDRKDCFTIDRISFFGVKENFDSLWASSKYNIFKKISENSFEAISYYSANPNGGSILKCILSWIWSFRGLFLEECKGCQDILHLDSPQYMYLPPSFRTFDNYTPYHPSCYQNHLLSCNSFSSSTSSSIQQSPFSPLNK
Length450
PositionTail
OrganismDictyostelium discoideum (Slime mold)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales> Dictyosteliaceae> Dictyostelium.
Aromaticity0.11
Grand average of hydropathy-0.587
Instability index68.85
Isoelectric point7.54
Molecular weight51863.59
Publications
PubMed=15875012
PubMed=18515835

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
transcription initiation from RNA polymerase II promoter	GO:0006367	ISS:dictyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31627
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.49|      15|      15|      10|      24|       1
---------------------------------------------------------------------------
    2-   17 (26.82/ 9.03)	QVQQPQQ.iQ.QQHLQQQ
   18-   34 (23.08/ 6.94)	QAQQHQQ.qQvQQHQQQQ
   35-   51 (22.59/ 6.67)	QQQQQQQqiY.QQIVNQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.88|      11|      43|     134|     144|       2
---------------------------------------------------------------------------
  134-  144 (20.38/11.94)	SYSFQIASSNF
  180-  190 (17.51/ 9.21)	SYKSSLASSNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.81|      16|      16|     226|     241|       3
---------------------------------------------------------------------------
  226-  241 (28.12/16.33)	LSTT..TITTTTTPSPLF
  243-  260 (23.69/12.79)	LPSTppTLLLSGTISPFY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.91|      48|     217|      60|     133|       4
---------------------------------------------------------------------------
   60-  101 (57.40/34.56)	.......SLQQQQLLEQYdELLKQVSLIRSNV....SDFFNSFI.....EDAKQQQTI
  213-  225 ( 1.85/ 8.50)	KKRKQISSLTSNS.............................................
  265-  321 (70.66/25.85)	QIERVIHSIRQESALEIF.EIQKQSSGAPKGLfvecPDVFKCLIcfgipNDRKDCFTI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31627 with Med27 domain of Kingdom Amoebozoa
Unable to open file!