<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31621

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQMRDRLLQAIDSQSNIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRPEMGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQQLDRADESPGPPYPRGSSRCSFSPRNSRHEGSFSRHRSSYIPKGQVSSPSPWPQPPDNTQVPSPLPLAQPPTPPVRRQELLPNAESPVHWPEQSEGHPRLTGPACRAGFSPDSSKADSDATSSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEVKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length588
PositionUnknown
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.04
Grand average of hydropathy-0.906
Instability index66.53
Isoelectric point9.29
Molecular weight64678.73
Publications
PubMed=16141072
PubMed=15489334
PubMed=21183079
PubMed=20111005

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31621
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.06|      36|      37|     280|     315|       1
---------------------------------------------------------------------------
  158-  181 (34.67/ 8.95)	......HPG..........PPHKVSKGSPDP.LVPNASPLP
  203-  238 (42.59/12.54)	GPdgsrLEPSDNEKHSTKIP...VNAVRPRP.SSPGLGK.P
  275-  313 (57.00/19.07)	P.rnsrHEGSFSRHRSSYIPKGQVSSPSPWP.QPPDNTQVP
  314-  352 (40.80/11.73)	SPlplaQPPTPPVRRQELLPNAE..SPVHWPeQSEGHPRLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.20|      18|      19|     438|     455|       2
---------------------------------------------------------------------------
  438-  455 (30.98/20.65)	PTEQLPRTELEQQEVKAS
  459-  476 (30.22/19.95)	PFEQTNWKELSRNEIIQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.03|      15|      22|     477|     493|       5
---------------------------------------------------------------------------
  477-  493 (22.28/17.73)	YLSRQSSllSSSGAQTP
  502-  516 (27.74/15.74)	YLKQEES..SRQGARQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.34|      15|      16|      95|     110|       8
---------------------------------------------------------------------------
   95-  110 (21.99/17.52)	RALAGAAGsANGGAHN
  112-  126 (28.35/17.81)	RPEMGVAG.APKSIHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31621 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWP
2) LRALAGAAGSANGGAHNCRPEMGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQQLDRADESPGPPYPRGSSRCSFSPRNSRHEGSFSRHRSSYIPKGQVSSPSPWPQPPDNTQVPSPLPLAQPPTPPVRRQELLPNAESPVHWPEQSEGHPRLTGPACRAGFSPDSSKADSDATSSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEVKASLQSPFEQ
495
94
549
462










Molecular Recognition Features






MoRF SequenceStartStop




1) RLKERKL
2) SKKKKRYRPRDYTVNLD
407
379
413
395