<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31620

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length600
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.04
Grand average of hydropathy-0.852
Instability index63.86
Isoelectric point9.27
Molecular weight65445.65
Publications
PubMed=9989412
PubMed=15489334
PubMed=10235267
PubMed=15175163
PubMed=15989967
PubMed=20111005
PubMed=23186163
PubMed=26861138

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome

GO - Biological Function
transcription coactivator activity	GO:0003713	TAS:ProtInc
transcription coregulator activity	GO:0003712	IDA:UniProtKB

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IDA:UniProtKB
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
transcription initiation from RNA polymerase II promoter	GO:0006367	TAS:ProtInc









Interaction





Binary Interactions
[O95402<-->Q96JC9: EAF1]	NbExp=5	EBI-394392,EBI-769261
[O95402<-->Q9NPJ6: MED4]	NbExp=11	EBI-394392,EBI-394607
[O95402<-->O43513: MED7]	NbExp=8	EBI-394392,EBI-394632
[O95402<-->Q8C1S0: Med19]	Xeno	NbExp=2,












Repeat regions





Repeats

>MDP31620
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     187.21|      25|      26|     252|     276|       1
---------------------------------------------------------------------------
  150-  182 (27.48/ 8.59)	RGDQRD..............lGHPGPP.PKvskashD..PlvP...NSSPLPT
  211-  246 (24.99/ 7.07)	R.DENDkhsgkipvnavrphtSSPGLGKPP......G..P.......C.LQPK
  252-  276 (50.43/22.64)	QLDRVD...............ETPGPPHPK......G..P..P...RCSFSPR
  280-  303 (30.72/10.57)	HEGSFA...............RQQSLYAPK......G..S.vP.....SPSPR
  344-  375 (24.81/ 6.96)	QPESHQ...............RLAGPGCKA......GlsPaePllsRAGFSPD
  378-  400 (28.78/ 9.39)	KADSDA...............ASSGGSDSK......K..K..K...R..YRPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.32|      14|     120|     194|     210|       2
---------------------------------------------------------------------------
  109-  123 (24.09/ 6.71)	HNCRPEvGAAGPPRS
  194-  207 (26.22/15.37)	SSLDGS.GHAGPEGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.78|      27|     102|     307|     339|       3
---------------------------------------------------------------------------
  307-  333 (46.33/16.82)	LDATQVPSPL..PLAQPSTPPVRRLELLP
  459-  487 (35.44/16.44)	LDKQEAKASLqsPFEQTNWKELSRNEIIQ
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31620 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSA
2) PVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQ
3) RLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGV
4) RQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWP
88
417
350
522
335
474
415
561










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) KKKKRYRPRDYTVNL
3) RRLELL
11
392
327
16
406
332