<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31619

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMNQNQIQQLTSHLSQALDQNYDVVNMDAVLSVICALEGTTITKEQLEATRLAKYINQLRRRTKNEHLARRAKSLLKMWREMVGIQQTANDSQHHHSQPTSLPTPPSAHFYKYTAGSADSNLTETVVHLPVSPSVPSHRTISDLHSNIDSSEPPPAVLPSQHQSNFLNLINNISKCEREESNSSMLIQAHKQPQSQQFQNRPLGLPLPFISEQSLNSVSISSDVGNDKKGEASIVIDIVTDSDENDNESASTIQGKPTAAASAPFTISPAPCPRPKKFKKDKKHKERDRSKSSLLAQNELIGQHSSRYSAKVKEGQSQTAQATDSEIFSLSNSSMSSILSGDAALLNPQHKFRANASELTFTGRFKPVNHLDSANQDNSALPIGQNIVFRQNESERPIFEDSITNDSSTSCSRLSPPTVEERRKSDKIDDSIRQQIATSIQMPMPSIGLGHESNSRTEYLENSSKSQVPKKRGRKKGSKGVDAVIAKESSSLSQQIFFGVGSTVKKVKTTKELFSEIQSRKLITAVQSPTSNISNSSISRELTTRALMPRPTSSCSDTSIHSPQIMETYSGNVTLMGVDKFSNKNEDAGNTDSDTITSEPSQDSNKSQEIKECTSLDSNSNSLQTLSLAKKSMHTSKSENYSDVTTQLMHLIHSIKGPLSVYEVEKLYRAQIVPCTCLVIEEICNPFGEPINLSSDNGVGDPKSDSNNDNVSRHKKQEEQLPKLERLSDNDFSMDTPQKPVKSIFDLDFDEDEDPLQSIINDIRMPPTKLEETKENADLKNALAHLPMNISSLDVASVNADTVQNQINSHNQEGETSEEQNVAIPVFTCHEDPDCVAKQRFHVQTNKVNNFHINALHNFYIPNINGNWDSIDSSIVSESTITDFLNTLGSYTVTDGADVVPKYGSLTYDRIRKDLSSIKFTSSFKTRPLKSFMPPFLGVAKCLPTCRLARSSFKKKQIQSPPPPLIVIPSTIEGLDPDIMQKDYNGGSPLKVDVDVLVSGHDNNESNVQMQVNLQTKSDPTLSYNLLKLANDELPFEETEPNDKGSEYENQDNGRFSSSSNSSCSNSSNSSLKKTQDSINEKLRNQRSQRYRVQSVEEETNRKRRGKNRKKRNIKENPPIKRIKISLNGTISNLSSSNNSSSSESETETGLENENEVENDYENNNDEEYAVVQRPTCGDGASNNHIVMTIKKTPSKINSPANSMSATSPINASETRNVKNAFSDSNRPNLLTSSTSIAPLYQIDGGRRLLLSKKFSRRPHRRRRYRQCRRKSDLQRKAIDLELKHLFTYKTKPDLDIGSAIKLHKKLFFSHELCKQNTAGRKERILNYSSSSSSNYDDDESDLDGLSSEETAADLKENVNTFNKYNLNIETDNTSAERTVSEDPLKIEEDPYLTSSSNDVTDSDNESDNHEVFDEVAKRVEADEFNELHNNGMLTSFNSISVENQLINEPTLMAVSGSVDTPAPQSNASLASLQNENCDDVNNLCYNNNNLDVIKHSLAASPILNDINYKNVISNTSPRVLANKFSDCIPQNIGNSELSPPIPLPCAEYQTGIRPAPLTDLALSSYADFRCTRIQQFKEWHQVLQLQSYNNEPLIVLPYVVLE
Length1602
PositionUnknown
OrganismDrosophila pseudoobscura pseudoobscura (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.751
Instability index55.57
Isoelectric point5.79
Molecular weight178179.49
Publications
PubMed=15632085

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31619
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1746.58|     499|     578|     386|     963|       1
---------------------------------------------------------------------------
    9-  384 (379.26/207.27)	.........................................................................................................................................................................................................................LTSHL.................SQALDQNYDVVNMDAVLSVICALEGTTITKEQLEATRLAKYINqlrRRTKN.......EHLARRA.KSLL......KMWREMVgIQQT...ANDSQHHHS..QPTSLPTPPSAHFYKytagsADSNLTETVVHLPVSPSVPSHRTISDLHSNIDSSEPP.PAVLP...SQHQSNFLNLINNI....SKCEREESNSSMliqahkqpqsqqfQNRPL.GLP...................LPfISeqSLNSVSISSD.VGN.....DKKGEAS....IVIDIVT.............................................DSDEndnesastiqgkPTAAASAPFTISPApcpRPKKFKKDKKHK........ERDRSKSSLLAQNE...LIGQHSS........RYSAKVKEGqSQTAQ.ATDSEIFSLSNSSMSSILSGDAALLNPQHKFRAnaselTFTGRFK.....PVNHL..DSANQDNSALPIGQ
  386-  963 (744.22/589.57)	IVFRQN.ESERPifeDSITNDSSTScsrlSPPtveerrksdKID.D...SIRQQIATSIQMpmpSIGLGHESNSRTEY.LENSSKSQVP..KKRGRKKGSKGVDAVIAKESSSlsqqiffgvgstvkkvkttkelfseiqsrklitaVQSPTSNISNSSISReltTRalmprptsscsDtSIhSPQIMETYSGNVTLMGVDKFSNKNEDAGNTDSDTITSEP.................SQDSNKSQEIKECTSLDSNSNSLQTLSLAKKSMHTSKSENYSD...VTTQL.......MHLIHSI.KGPLSvyeveKLYRAQI.VPCTclvIEEICNPFG..EPINLSSDNGVGDPK.....SDSNNDNVSRHKKQEEQLPKLERLSDNDFSMDTPQKPVKSIFDLDFDEDEDPLQSIINDIRMPPTKLEETKENADL.............KNALA.HLP...................MN.IS..SLDVASVNADTVQNQINSHNQEGETSEEQNVAIPVFT.............................................CHED............PDCVAKQRFHVQTN...KVNNFHINALHNfyIPNINGNWDSIDSSIVSEST...ITDFLNT........LGSYTVTDG.ADVVP.KYGSLTYDRIRKDLSSIKFTSSFKTRPLKSFMP.....PFLGVAK...CLPTCRLARSSFKKKQIQSPPPP
  965- 1542 (623.10/374.92)	IVIPSTiEGLDP...DIMQKDYNGG....SPL.........KVDvDvlvSGHDNNESNVQM...QVNLQTKSDPTLSYnLLKLANDELPfeETEPNDKGSEYENQDNGRFSSS..................................SNSSCSNSSNSSLKK...TQ...........D.SI.NEKLRNQRSQRYRVQSVEEETNRKRRGKNRKKRNIKENPpikrikislngtisnlsSSNNSSSSESETETGLE.NENEVE......NDYENNNDEEYAV...VQRPTcgdgasnNHIVMTIkKTPSK....................INSPANSMSatSPINASETRNVKNAF.....SDSNRPNLLTSSTSIAPLYQIDGGRRLLLSKKFSRRPHRRRRYRQCRRKSD.LQRKAIDLELKHLFTYKTKPDLDI.............GSAIKlHKKlffshelckqntagrkeriLN.YS..S..SSSSNYDDDESDLDGLSSE.ETAADLKENVNTFNkynlnietdntsaertvsedplkieedpyltsssndvtdsdnesdNHEV............FDEVAKR...VEAD...EFNELHNNGM....LTSFNSI..SVENQLINEPTlmaVSGSVDTpapqsnasLASLQNENC.DDVNNlCYNNNNLDVIKHSLAASPILNDINYKNVISNTS.....PRVLANKfsdCIPQ.NIGNSEL......SPPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.23|      16|      17|    1366|    1381|       3
---------------------------------------------------------------------------
 1366- 1381 (26.53/14.85)	LNIETDN..TSAERTVSE
 1384- 1401 (22.69/11.49)	LKIEEDPylTSSSNDVTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31619 with Med26 domain of Kingdom Metazoa
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