<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31617

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMTTASATPQQMRDRLLQAIDSHSNICNMVAVLDVITNLEKYPITKEALEETRLGKLINDVRKKTKDEDLAKRAKKLLRNWQKLIEPGQGDTPVRGPPNVPGSANGGAHPCRTDTPPAVPPPSKVAPELKTRNDIHNTYSPKAEKSSSRKRRAEQRDSPHLPAKMSKTSLYEPVYSSSPPSNGIRGTPEPLLEKDDEVPSDRIRLEHLDNDRHNKIPVNAVKPHPSSPGLTKLPSTSSLLKASVLQQARVDSGGQHQPKSPRYSSSPRSATHETMAKRSTTYAPKGTLSSPSLNSAQVPSPLPTLQPLTSPAQVCISDGPSSVGLEGSLHLHRSSDRVSQPPHSTATLEPLSGALLATHGLEGLETKAEREGASSNSDGKKRKKYRPRDYTVNLQGQSSEDRTKPRLKERRLTFDPVTGQIKPLTPKESHQEEECHGQPIPEPSVRTDIPQQKPPTSVPNPFQQTNWKELSRNEIIQSYLNLQSNVLTSSGAQTHGAHFFMTEYLKREEHDVKEPRKMHVLAPGSSTTELPGVSRDVTNEDLLRIHNEHWPGVNGCYDTKGAWFDWTDCISLDPHGDESKLNILPYVCLD
Length589
PositionUnknown
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.04
Grand average of hydropathy-0.880
Instability index60.14
Isoelectric point8.90
Molecular weight65029.16
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISS:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31617
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.10|      12|      16|      89|     100|       1
---------------------------------------------------------------------------
   89-  100 (24.51/12.03)	GDTPVR..GPPNVP
  106-  119 (19.58/ 7.96)	GAHPCRtdTPPAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.49|      14|      15|     283|     297|       2
---------------------------------------------------------------------------
  283-  297 (20.88/13.19)	PKGTLsSPSLNSAQV
  300-  313 (26.61/12.96)	PLPTL.QPLTSPAQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.12|      15|      15|     184|     198|       3
---------------------------------------------------------------------------
  184-  198 (26.02/12.71)	RGTPEPL.LEKDDEVP
  201-  216 (19.11/ 7.30)	RIRLEHLdNDRHNKIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.62|      13|      15|     375|     387|       5
---------------------------------------------------------------------------
  375-  387 (23.40/12.68)	NSDGKKRK.KYRPR
  392-  405 (18.22/ 8.33)	NLQGQSSEdRTKPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.82|      38|      76|      42|      88|       9
---------------------------------------------------------------------------
   42-   88 (50.76/53.80)	PITKEALE.ETRlgkliNDVR.....KKTKDEDLAKRAKKllRNWQKLiePGQ
  120-  163 (57.06/35.67)	PPSKVAPElKTR.....NDIHntyspKAEKSSSRKRRAEQ..RDSPHL..PAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31617 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EETRLGKLINDVRKKTKDEDLAKRAKKLLRNWQKLIEPGQGDTPVRGPPNVPGSANGGAHPCRTDTPPAVPPPSKVAPELKTRNDIHNTYSPKAEKSSSRKRRAEQRDSPHLPAKMSKTSLYEPVYSSSPPSNGIRGTPEPLLEKDDEVPSDRIRLEHLDNDRHNKIPVNAVKPHPSSPGLTKLPSTSSLLKASVLQQARVDSGGQHQPKSPRYSSSPRSATHETMAKRSTTYAPKGTLSSPSLNSAQVPSPLPTLQPLTSPAQVCISDGPSSVGLEGSLHLHRSSDRVSQPPHSTATLEPLSGALLATHGLEGLETKAEREGASSNSDGKKRKKYRPRDYTVNLQGQSSEDRTKPRLKERRLTFDPVTGQIKPLTPKESHQEEECHGQPIPEPSVRTDIPQQKPPTSVPNPFQQTNWKE
49
468










Molecular Recognition Features






MoRF SequenceStartStop




1) KLLRNWQKLI
2) LYEPVY
75
169
84
174