<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31616

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMTAAPPSPQQIRDRLLQAIDPQSNIRNMVAVQEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQNEAALRGLAGAPGSANGGAHNCRPEAGAAGPPKSVHDLKYRNDMPRLCGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGISGSPESFPSPLDSSGHVGPEGNRLEHGENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQTKAVVLQQLDKVDETPGPPHPKGPPRCSLGSRNSRHEGSFARQRSPYTYKGSLPSPSPRPQSLDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPEGHQRLAGLGCKAGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARKPHVLVPHGPPTDFPGLSREVTRDDLDKIQAHQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length599
PositionUnknown
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.04
Grand average of hydropathy-0.890
Instability index60.12
Isoelectric point9.46
Molecular weight65513.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional pre-initiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	ISS:UniProtKB

GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31616
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.60|      24|      26|     298|     321|       1
---------------------------------------------------------------------------
  222-  245 (34.64/ 9.54)	PVNAVRPH.TSSPGLGKPPGPCLQT
  263-  287 (30.31/ 7.50)	PHPKGPPRcSLGSRNSRHEGSFARQ
  298-  321 (44.65/14.24)	PSPSPRPQ.SLDATQVPSPLPLAQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     313.13|      65|     109|     324|     390|       2
---------------------------------------------------------------------------
  172-  202 (33.53/ 9.00)	..........................................SL.VPNS.SP....LPTNGISGSPES..FPSP.LDSSGHV
  324-  390 (108.99/51.28)	PPVRRL..ELLPS.....AESPVRWLEQPegHQRLAGLGCKAGL.PPAE.PL....LPRAGFSPDSSK..ADSDAASSGGSD
  429-  502 (85.69/35.37)	PMTRQI..KPLTQkepvrADSPVH.TEQP..RTELDKPEAKASLqSPFE.QTnwkeLSRNEIIQSYLS..RQSSLLSSSGAQ
  504-  567 (84.91/34.99)	PGAHHFmsEYLKQ.....EESTRRGARKP..H.VLVPHG......PPTDfPG....LSREVTRDDLDKiqAHQWPGVNGCQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.05|      20|     267|     128|     156|       3
---------------------------------------------------------------------------
  123-  142 (35.56/17.36)	SVHDLKYRNDMPRLCGQRLD
  152-  171 (35.49/14.11)	DQRDLGHPGPPPKVSKASHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31616 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQNEAALRGLAGAPGSANGGAHNCRPEAGAAGPPKSVHDLKYRNDMPRLCGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGISGSPESFPSPLDSSGHVGPEGNRLEHGENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQTKAVVLQQLDKVDETPGPPHPKGPPRCSLGSRNSRHEGSFARQRSPYTYKGSLPSPSPRPQSLDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPEGHQRLAGLGCKAGLPPAEPLLPRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGV
2) PVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHTEQPRTELDKPEAKASLQSPFEQTNW
3) RQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARKPHVLVPHGPPTDFPGLSREVT
88
417
491
415
476
547










Molecular Recognition Features






MoRF SequenceStartStop




1) QIRDRLLQAID
2) RLKERKL
3) RRLELL
4) SKKKKRYRPRDYTVNLDGQV
10
419
327
391
20
425
332
410