<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31615

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMDAATPGNGGIISDVVFVIEGTANLGPYFESLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVQWLDSIRFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHKVCILICNSPPYLLPAVESTTYSGYTTENLVQKIGERGIHFSVISPRKLPALRTLFEKAMPVGLIEPQPKDYSQDPRHMILVRGMVLPVGGATSVPGVIPPKQPISQPPLPVVPPQIANAPSHQLPPVQPPYMQVPQQNTLTTAHAAAQSAVEAAKNQKNNLPNRFPLPNLNQMPPTSAVGTPFNQPPPPAMPQNTSVPKMVTSTASLMTPASQPSLVTTVTTGPGPAPVQLQQQGAQQQPVPPSMPITGAAGGVQAPQPSQPQIGTAQLPCTQTPVNGNKLLAWSGVLEWQEKPRSVSVDNNAKLTRSLPCQVYVNPGENLKTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGSGFQAGCVHFPHTTPCEVRVLMLLYSSKKKIFMGLIPNDQSGFVNGIRQVITNHKQVQMQKIDQQRNMGAGQAVGTGNVPANTQAFLQKQPGALPVAQAVPQQMQGQQVAPGMPSISQVTMMDEQQRTQNLLHIRVQQPQQAASQAPPQATQTTVQAPGQPQNPQPGAMLRPQNPGANPQLRNLLLSQQPPQTSVPQTQQPLHHMQQAAQGMLPHQAMGQQMQHQAPGQQQLQLPGQTLMHQAPAQQWGNQMQQRAPIPGTLMMSAGPRGPVPQQGLQQVQAQSVMEDDILMDLI
Length805
PositionUnknown
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Amphibia> Batrachia> Anura> Pipoidea> Pipidae> Xenopodinae> Xenopus> Silurana.
Aromaticity0.05
Grand average of hydropathy-0.368
Instability index55.33
Isoelectric point8.82
Molecular weight87142.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31615
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     364.50|      50|      51|     658|     707|       1
---------------------------------------------------------------------------
  224-  273 (61.57/17.76)	P.VG..GATSV..PGviPPK..QP..ISQP..PLP....VVPPQIA.....NAP.SH.....QlppvQPPYM.QVPQ
  281-  316 (43.67/10.20)	H.AA..AQSAVEAAK..NQKNNLPNRF...............P.LP.....NL...N.....Q....MPPTS.AV..
  386-  438 (47.07/11.63)	...G..AAGGVQAP...QPSQPQIGTAQLPctQTP....VNGNKL.......LA.WSgvlewQ....EKPRSvSVDN
  611-  655 (55.81/15.33)	P.QQ..MQGQQVAPG..MPSISQV.TMMDE..QQ.........RTQ.....NLLhIR.....V....QQPQQ.AASQ
  658-  707 (96.43/32.50)	P.QA..TQTTVQAPG..QPQNPQPGAMLRP..QNP....GANPQLR.....NLL.LS.....Q....QPPQT.SVPQ
  724-  784 (59.96/17.08)	PhQAmgQQMQHQAPG..QQQLQLPGQTLMH..QAPaqqwGNQMQQRapipgTLM.MS.....A.....GPRG.PVPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.44|      26|      27|     480|     506|       2
---------------------------------------------------------------------------
  480-  506 (43.34/24.82)	LGPLFRNSrMVQF.HFTNKDLESLKGLY
  509-  535 (44.09/21.39)	MGSGFQAG.CVHFpHTTPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.65|      18|     268|     317|     334|       5
---------------------------------------------------------------------------
  317-  334 (36.14/11.79)	GTPFNQPPPPAMPQNTSV
  345-  362 (29.51/ 8.39)	MTPASQPSLVTTVTTGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.08|      24|      27|     549|     574|       7
---------------------------------------------------------------------------
  455-  475 (33.43/12.34)	.GENLKTDQWP...QKLIMQLIPQQ
  551-  575 (35.92/22.39)	SGFVNGIRQVITNhKQVQMQKIDQQ
  580-  599 (26.73/10.53)	AGQAVGTGNVPAN.TQAFLQK....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31615 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGVIPPKQPISQPPLPVVPPQIANAPSHQLPPVQPPYMQVPQQNTLTTAHAAAQSAVEAAKNQKNNLPNRFPLPNLNQMPPTSAVGTPFNQPPPPAMPQNTSVPKMVTSTASLMTPASQPSLVTTVTTGPGPAPVQLQQQGAQQQPVPPSMPITGAAGGVQAPQPSQPQIGTAQLPCT
2) QMQKIDQQRNMGAGQAVGTGNVPANTQAFLQ
3) QPGALPVAQAVPQQMQGQQVAPGMPSISQVTMMDEQQRTQNLLHIRVQQPQQAASQAPPQATQTTVQAPGQPQNPQPGAMLRPQNPGANPQLRNLLLSQQPPQTSVPQTQQPLHHMQQAAQGMLPHQAMGQQMQHQAPGQQQLQLPGQTLMHQAPAQQWGNQMQQRAPIPGTLMMSAGPRGPVPQQGLQQVQAQ
232
568
600
409
598
793










Molecular Recognition Features






MoRF SequenceStartStop




NANANA