<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31611

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMEVDQIPLADVVFVIEGSAINGAYINELKTNYILPTLEHFTTGSIDEREYLIAERFATLYGIVVYRTAANLLEPVCSTYGPFLQPQKVMETIERLPLVGGGMESCAHMAEGFAAAHGCFDDISERRQLLDQTSVQRHCILICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMPVLFKLFMKADGDQPITSKNYAKNIRHLVLLKGYSLKERAPSPNSMAAQMAAPNAAQATVQQQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMNTMQQQQPGPNPPAGLLNPQQQQQLLQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGGVGQGGGMQQNPNSALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQQQMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNPQQQGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQKIPHTLQCTVCTNIKDGEPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDSKMVVFRPTPGEALDSLAKMMTSGYAGCVHFSSIPNSPACDLKVLILLYTPDRNAFLGFIPNNQAMFVERLRKVIQQKQHGNMQQQQQQQQMMQQQGKSPMELQQQQQQQQQQQQMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAGGPMVGNRNFDDGNYEFM
Length863
PositionUnknown
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.916
Instability index63.49
Isoelectric point8.77
Molecular weight96640.68
Publications
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=16751183

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes. 
ECO:0000250	
ECO:0000269	PubMed:16751183
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB
nucleoplasm	GO:0005654	ISS:FlyBase
transcription regulator complex	GO:0005667	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	ISS:UniProtKB
GO - Biological Process
nervous system development	GO:0007399	IMFlyBase
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	IMFlyBase
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	ISS:UniProtKB

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31611
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     526.39|      96|     130|     203|     304|       1
---------------------------------------------------------------------------
  203-  303 (178.24/41.59)	KNYAKnirhlVLLKGYSLKERAPS.PNS.MAAQMA................APNAAQATVQQ.....QQQQQ......QNQAGQQQQ......GQGM......PMDTTPA.........QQQQQQQQQQQQQQQ.....QGNPQQQVMNMNTMQQQ
  304-  383 (89.20/13.89)	.....................QPG.PNP..PAGLL................NPQQQQQLLQQ.....QQQNQfvsnqmQNQNFQQNV......GPGQ......NRWMYPN.........QPGQARPPFMQGAGNvggvgQGGGMQQ..........
  384-  448 (100.05/16.83)	.......................N.PNSaLISRIN................APPPNQ.TVTS.....LQQQQ......QQQA.QQQ.................................QQQQQQAQQQQQQRM.....QMLSQQQMLNHQQLQQQ
  453-  508 (43.17/ 6.36)	............................................................QQ.....QQQQQ......Q...GQQQQqvnpnaGNNM.......M...PAsnagnmsnpQQQQQQVGQQSNPQQ.....QGNPQQ...........
  606-  718 (115.72/20.52)	DSLAK.....MMTSGYAGCVHFSSiPNS.PACDLKvlillytpdrnaflgfIPNNQAMFVERlrkviQQKQH......GNMQQQQQQ......QQMMqqqgksPMEL.............QQQQQQQQQQQQMQ.....QDNSQQQHYN.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.06|      34|      37|     722|     758|       2
---------------------------------------------------------------------------
  722-  750 (56.20/16.19)	.......LNMQMG.GGGPGGGPGP.........GPGGMPMQQNQMQ
  754-  799 (43.56/13.96)	MQQQRmpLGVGVGvGVGPGGVPNPnlqqqlqqvAPNVAAMQQQQAQ
  800-  832 (50.29/11.77)	QQQQR.mVRPMMS.NNNPGLRQLL.........QHQTTP..GNQFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.71|      57|     408|     130|     189|       3
---------------------------------------------------------------------------
  130-  189 (90.16/64.33)	DQTSVQrH...CiLICNSPPYQMPTTESWKYPGKSCEQLAALFNERKINLSIIAPRKMpVLFK
  539-  598 (98.54/57.20)	DQQKIP.HtlqC.TVCTNIKDGEPEIKAENWPPKLLMQLMPKHLVGNIGGQFLKDSKM.VVFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31611 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KGYSLKERAPSPNSMAAQMAAPNAAQATVQQQQQQQQNQAGQQQQGQGMPMDTTPAQQQQQQQQQQQQQQQQGNPQQQVMNMNTMQQQQPGPNPPAGLLNPQQQQQLLQQQQQNQFVSNQMQNQNFQQNVGPGQNRWMYPNQPGQARPPFMQGAGNVGGVGQGGGMQQNPNSALISRINAPPPNQTVTSLQQQQQQQAQQQQQQQQQAQQQQQQRMQMLSQQQMLNHQQLQQQQQLAQQQQQQQQGQQQQQVNPNAGNNMMPASNAGNMSNPQQQQQQVGQQSNPQQQGNPQQQQQGNSQQEQASLREKIWTGVLEWSEKPKSDQQKIPHTLQCT
2) RLRKVIQQKQHGNMQQQQQQQQMMQQQGKSPMELQQQQQQQQQQQQMQQDNSQQQHYNQFQLNMQMGGGGPGGGPGPGPGGMPMQQNQMQMNMMQQQRMPLGVGVGVGVGPGGVPNPNLQQQLQQVAPNVAAMQQQQAQQQQQRMVRPMMSNNNPGLRQLLQHQTTPGNQFRPQMGGQNPNQMGAGGPMVGNRNFDDGNYEFM
216
661
550
863










Molecular Recognition Features






MoRF SequenceStartStop




NANANA