<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31610

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMDPTSKSGLNQVSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADSLVQIIRDRGIHFSVIAPRKLPALRSLFERASSVAGLPESSHPDYSQDPFHMVLVRGIALPVAPGGGSVPVSLKPVLPPQSLPVNQNPLVPVASTAPQMNTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVANKVVAWSGVLEWQEKPKASSMDSNTKLTRSLPCQVQVSQGENLNTDQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDMESLKGLFRIMTSGFAGCVHFPHSAPCEVRVLMLLYSSRKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPQGGMQGMQGMHPIQQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVMEDEILMDLI
Length701
PositionUnknown
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.06
Grand average of hydropathy-0.309
Instability index54.08
Isoelectric point8.05
Molecular weight75462.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity). 


ECO:0000250	

GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
roof of mouth development	GO:0060021	IMZFIN









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31610
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     301.11|      44|      44|     564|     607|       1
---------------------------------------------------------------------------
  227-  298 (32.98/ 6.65)	APGGgsvpvslkpvlpPQSLPVNQNPLvpvastaPQmntfqnvSLHAAHDAA...QKAL.EEAA..N.....QQQknrfG.QIS
  299-  342 (47.90/13.06)	TPPF.....sqspvlpPGGKP.SLSTV........T.......TVSPPVLTQ...QQ......VPPQ.....QPQ....Q.QTQ
  343-  373 (32.22/ 6.33)	VPQP......glpavnQQP.PQASQQQ.......P...............NN...QQTP.....PPT.....Q...........
  374-  427 (34.04/ 7.11)	.PGM.........aavPAPPPGAQQGV.......AN.......KV.VAWSGVlewQEKPkASSMDSNtkltrSLP....C.QVQ
  564-  603 (67.40/21.44)	................PGPIPVTHGNV.......PQ.......QLRAAATGN...QQAP.VTGAPPN.....QVQ....G.QAQ
  604-  640 (37.24/ 8.49)	APGG.....gmlrlqnPGANP......................QLRSLLLSQ...Q........PQG.....GMQ....GmQGM
  641-  681 (49.33/13.68)	HPIQ......qmvhaaPG....GGAQM.......QP.......QWRQPHQGP...LMVP..TG.PRG.....PV........TQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.77|      36|      55|      46|     100|       2
---------------------------------------------------------------------------
   41-   82 (52.68/71.03)	IEYfnGGppAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCH
   98-  136 (52.09/24.79)	IQFmgGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.49|      22|      38|     460|     489|       4
---------------------------------------------------------------------------
  476-  507 (26.30/22.35)	ESLKGLFRIMTSGF..agcvhFPHSapcevRVLM
  515-  543 (32.19/ 8.73)	RIFMGLIPNDQSGFvngirqvITNH.....KQVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31610 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQRSMQPGQVQPNQNFLNRPPGPIPVTHGNVPQQLRAAATGNQQAPVTGAPPNQVQGQAQAPGGGMLRLQNPGANPQLRSLLLSQQPQGGMQGMQGMHPIQQMVHAAPGGGAQMQPQWRQPHQGPLMVPTGPRGPVTQNPGMPSVSSVME
2) NTFQNVSLHAAHDAAQKALEEAANQQQKNRFGQISTPPFSQSPVLPPGGKPSLSTVTTVSPPVLTQQQVPPQQPQQQTQVPQPGLPAVNQQPPQASQQQPNNQQTPPPTQPGMAAVPAPPPGAQQGVA
539
264
693
391










Molecular Recognition Features






MoRF SequenceStartStop




NANANA