<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31608

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMSSEVKQLIVVAEGTAALGPYWQTIVSDYLEKIIRSFCGSELNGERNPVSTVELSLVIFNSHGSYCACLVQRSGWTRDVDIFLHWLSSIQFGGGGFNEVATAEGLAEALMMFSPPSGQAQPSNDLKRHCILITASNPHILPTPVYRPRLQNVERNENGDAQAESRLSDAETVASYFAKCSVSLSVVCPKQLPTIRALYNAGKPNQQSADLSIDTAKNTFYLVLISENFVEACAALSHSATNLPQTQSPVKVDRATVAPSIPVTGQPPAPVSSANGPIQNRQPVSVGPVPTATVKVEPSTVTSMAPVPSFPHIPAVARPATQAIPSIQTSSASPVSQDMVSNAENAPDIKPVVVSGMTPPLRTGPPGGANVNLLNNLSQVRQVMSSAALAGAASSVGQSAVAMHMSNMISTGMATSLPPSQTVFSTGQQGITSMAGSGALMGSAQTGQSPGPNNAFSPQTTSNVASNLGVSQPMQGMNQGSHSGAMMQGGISMNQNMMSGLGQGNVSSGTGGMMPTPGVGQQAQSGIQQLGGSNSSAPNMQLSQPSSGAMQTSQSKYVKVWEGNLSGQRQGQPVLITRLEGYRSASASDSLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMSQHGFLGQLQDKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPNQQQQQQQQLHQQQQQQQQIQQQQQQQQHLQQQQMPQLQQQQQQHQQQQQQQHQLSQLQHHQQQQQQQQQQQQQHQLTQLQHHHQQQQQASPLNQMQQQTSPLNQMQQQTSPLNQMQQQQQPQQMVMGGQAFAQAPGRSQQGGGGGQPNMPGAGFMG
Length836
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.04
Grand average of hydropathy-0.454
Instability index61.22
Isoelectric point8.51
Molecular weight89564.66
Publications
PubMed=12815435
PubMed=11130712
PubMed=27862469
PubMed=16183832
PubMed=17560376
PubMed=18790998
PubMed=19671879
PubMed=21343311
PubMed=22021418
PubMed=21536906
PubMed=21985558
PubMed=22447446
PubMed=22822206
PubMed=22992513

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Positive regulator of shade avoidance and of jasmonate signaling. Acts in repression of PhyB- mediated light signaling and regulates the expression of FLOWERING LOCUS T (FT) and of CONSTANS (CO). 
ECO:0000269	PubMed:12815435
ECO:0000269	PubMed:17560376
ECO:0000269	PubMed:18790998
ECO:0000269	PubMed:19671879
ECO:0000269	PubMed:21536906
ECO:0000269	PubMed:21985558
GO - Cellular Component
mediator complex	GO:0016592	IDA:TAIR
nucleus	GO:0005634	IDA:TAIR
transcription regulator complex	GO:0005667	IBA:GO_Central
GO - Biological Function
DNA binding	GO:0003677	IDA:UniProtKB
transcription coactivator activity	GO:0003713	NAS:TAIR
GO - Biological Process
defense response to fungus	GO:0050832	IMTAIR
flower development	GO:0009908	IEA:UniProtKB-KW
jasmonic acid mediated signaling pathway	GO:0009867	IMTAIR
positive regulation of defense response	GO:0031349	IMTAIR
positive regulation of flower development	GO:0009911	IMTAIR
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
positive regulation of transcription, DNA-templated	GO:0045893	IMTAIR
red, far-red light phototransduction	GO:0009585	IMTAIR
regulation of flower development	GO:0009909	IMTAIR
response to far red light	GO:0010218	IMTAIR
response to red light	GO:0010114	IMTAIR
trichome branching	GO:0010091	IMTAIR
trichome papilla formation	GO:1905499	IMTAIR

Interaction

Binary Interactions
[Q7XYY2<-->P06492: UL48]	Xeno	NbExp=2,
[Q7XYY2-1<-->O82132: DREB2A]	NbExp=3	EBI-15924435,EBI-1786840
[Q7XYY2-1<-->Q9FIP9: MYC3]	NbExp=2	EBI-15924435,EBI-15845995
[Q7XYY2-1<-->Q8GUN5-2: PHL1]	NbExp=2	EBI-15924435,EBI-15924466
[Q7XYY2-1<-->Q9SEZ1: ZHD11]	NbExp=3	EBI-15924435,EBI-1806317

Repeat regions

Repeats

>MDP31608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     147.88|      19|      19|     716|     734|       1
---------------------------------------------------------------------------
  698-  714 (34.48/ 9.07)	QIQ..QQQ...Q..QQQHLQQQQM
  716-  734 (44.00/13.61)	QLQ..QQQ...QQHQQQQQQQHQL
  736-  756 (37.93/10.71)	QLQhhQQQ...QQQQQQQQQQHQL
  784-  805 (31.47/ 7.63)	QMQ..QQTsplNQMQQQQQPQQMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     411.40|      70|      70|     435|     504|       2
---------------------------------------------------------------------------
  234-  305 (64.61/19.53)	...ALSHS......AtnlpQT...QSPVkvdratvaPSIPVTGQPPAPVSSANG.PIQN..RQPVSVGPVPT..ATVKVEPSTV.TSMAP......
  319-  383 (85.58/28.24)	ATQA.IPS......I....QT...SSAS........P...VSQDMVSN.AENAP.DIKPvvVSGMTPPLRTG..P..PGGANVNlLNNLSQVRQVM
  384-  430 (57.32/16.50)	SSAALAGA......A....SSvG.QS............................aVAMH..MSNM...ISTG....MATSLPPS.QTVFSTGQQGI
  435-  504 (129.34/46.42)	GSGALMGS......A....QT.G.QSPG........PNNAFSPQTTSNVASNLG.VSQP..MQGMNQGSHSG..AMMQGGISMN.QNMMSGLGQGN
  508-  571 (74.54/23.65)	GTGGMMPTpgvgqqA....QS.GiQQLG........GSNSSAP........NMQ.LSQP..SSGAMQTSQSKyvKVWEGN........LSGQRQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.69|      11|      70|     686|     696|       3
---------------------------------------------------------------------------
  686-  696 (23.36/ 7.15)	QQQLHQQQQQQ
  758-  768 (23.33/ 7.13)	QLQHHHQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.18|      15|      18|     631|     647|       4
---------------------------------------------------------------------------
  631-  646 (20.92/11.29)	FLGQLQDKKlCAVIQL
  651-  665 (23.26/10.10)	LLLSVSDKA.CRLIGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      10|      19|     807|     816|       5
---------------------------------------------------------------------------
  807-  816 (19.18/ 7.81)	GGQAFAQAPG
  824-  833 (20.95/ 9.26)	GGQPNMPGAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.76|      11|     170|     135|     147|       6
---------------------------------------------------------------------------
  135-  147 (15.95/15.28)	SNPHIlPTpVYRP
  308-  318 (23.81/11.48)	SFPHI.PA.VARP
---------------------------------------------------------------------------


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP31608 with Med25 domain of Kingdom Viridiplantae



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATNLPQTQSPVKVDRATVAPSIPVTGQPPAPVSSANGPIQNRQPVSVGPVPTATVKVEPSTVTSMA
2) MAGSGALMGSAQTGQSPGPNNAFSPQTTSNVASNLGVSQPMQGMNQGSHSGAMMQGGISMNQNMMSGLGQGNVSSGTGGMMPTPGVGQQAQSGIQQLGGSNSSAPNMQLSQPSSGA
3) QQQQHQLSQLQHHQQQQQQQQQQQQQHQLTQLQHHHQQQQQASPLNQMQQQTSPLNQMQQQTSPLNQMQQQQQPQQMVMGGQAFAQAPGRSQQGGGGGQPNMPGAGFMG
4) RPATQAIPSIQTSSASPVSQDMVSNAENAPDIKPVVVSGMTPPLRTGPPGGANVNLLNN
239
433
728
317
304
548
836
375










Molecular Recognition Features






MoRF SequenceStartStop




1) AFAQA
810
814