<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31607

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGSAVTGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASSWTAIEHCLLKLGEILANLSNPQLRSQAEHCGTLIRSIPTMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEASFASLVSKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYISLFPVEDMQPSKLMRLLSSNEDDASILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSVLGSRTAGPHTQFVQWFMEECVDCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length987
PositionTail
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy0.030
Instability index46.21
Isoelectric point6.28
Molecular weight110079.86
Publications
PubMed=15489334
PubMed=22673903

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	IDA:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IDA:RGD
protein-containing complex binding	GO:0044877	IDA:RGD
thyroid hormone receptor binding	GO:0046966	ISO:RGD
transcription coactivator activity	GO:0003713	IDA:RGD
transcription coregulator activity	GO:0003712	ISO:RGD

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
stem cell population maintenance	GO:0019827	ISO:RGD
transcription by RNA polymerase II	GO:0006366	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31607
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.92|      14|      16|     276|     290|       1
---------------------------------------------------------------------------
  276-  290 (22.58/17.21)	IPTPLFVLEI.WKAcF
  294-  308 (22.34/10.95)	IESPEGTQELkWTA.F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.56|      60|     256|      63|     126|       2
---------------------------------------------------------------------------
   63-  126 (94.32/72.63)	YLKYAISSQMvsySSVLTAISKFDDFSR....DLCVQALLDIMDMFCDRLScHGKAEECIGLCR...ALLS
  164-  230 (89.25/55.84)	CLEKTLSSTK...NRALLHIAKLEEASSwtaiEHCLLKLGEILANLSNPQL.RSQAEHCGTLIRsipTMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.73|      51|     115|     614|     668|       7
---------------------------------------------------------------------------
  614-  668 (76.57/69.55)	LAVCAVAWLVAHV..RMLGLDEREKSLQMIrQLagpLYSENTLQFYNERVVIMNSIL
  734-  786 (85.15/61.94)	LHMGGVYWFCNNLikELLKETRKEHTLRAV.QL...LYSIFCLDMQQVTLVLLGHIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31607 with Med24 domain of Kingdom Metazoa
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