<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31607

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGSAVTGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASSWTAIEHCLLKLGEILANLSNPQLRSQAEHCGTLIRSIPTMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEASFASLVSKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYISLFPVEDMQPSKLMRLLSSNEDDASILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSVLGSRTAGPHTQFVQWFMEECVDCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length987
PositionTail
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.07
Grand average of hydropathy0.030
Instability index46.21
Isoelectric point6.28
Molecular weight110079.86
Publications
PubMed=15489334
PubMed=22673903

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	ISO:RGD
nucleus	GO:0005634	IDA:RGD
ubiquitin ligase complex	GO:0000151	IDA:RGD

GO - Biological Function
histone acetyltransferase activity	GO:0004402	IDA:RGD
protein-containing complex binding	GO:0044877	IDA:RGD
thyroid hormone receptor binding	GO:0046966	ISO:RGD
transcription coactivator activity	GO:0003713	IDA:RGD
transcription coregulator activity	GO:0003712	ISO:RGD

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:RGD
positive regulation of transcription, DNA-templated	GO:0045893	ISO:RGD
protein ubiquitination	GO:0016567	IDA:RGD
stem cell population maintenance	GO:0019827	ISO:RGD
transcription by RNA polymerase II	GO:0006366	ISO:RGD









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP31607
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.92|      14|      16|     276|     290|       1
---------------------------------------------------------------------------
  276-  290 (22.58/17.21)	IPTPLFVLEI.WKAcF
  294-  308 (22.34/10.95)	IESPEGTQELkWTA.F
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.56|      60|     256|      63|     126|       2
---------------------------------------------------------------------------
   63-  126 (94.32/72.63)	YLKYAISSQMvsySSVLTAISKFDDFSR....DLCVQALLDIMDMFCDRLScHGKAEECIGLCR...ALLS
  164-  230 (89.25/55.84)	CLEKTLSSTK...NRALLHIAKLEEASSwtaiEHCLLKLGEILANLSNPQL.RSQAEHCGTLIRsipTMLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.73|      51|     115|     614|     668|       7
---------------------------------------------------------------------------
  614-  668 (76.57/69.55)	LAVCAVAWLVAHV..RMLGLDEREKSLQMIrQLagpLYSENTLQFYNERVVIMNSIL
  734-  786 (85.15/61.94)	LHMGGVYWFCNNLikELLKETRKEHTLRAV.QL...LYSIFCLDMQQVTLVLLGHIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31607 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA