<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31606

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSCSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGTPAPGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAERCGTLIRSIPSMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGEKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEVNFASLVGKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYVSLFPVEDMQPSKLMRLLSSSDDDANILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVGCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length987
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy0.026
Instability index47.49
Isoelectric point6.38
Molecular weight109983.82
Publications
PubMed=10406464
PubMed=11471062
PubMed=16141072
PubMed=19468303
PubMed=15489334
PubMed=12093747
PubMed=11934987
PubMed=17242355
PubMed=21183079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	ISO:MGI
ubiquitin ligase complex	GO:0000151	ISO:MGI

GO - Biological Function
histone acetyltransferase activity	GO:0004402	ISO:MGI
protein-containing complex binding	GO:0044877	ISO:MGI
thyroid hormone receptor binding	GO:0046966	ISO:MGI
transcription coactivator activity	GO:0003713	ISO:MGI
transcription coregulator activity	GO:0003712	ISO:MGI

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:MGI
positive regulation of transcription, DNA-templated	GO:0045893	ISO:MGI
protein ubiquitination	GO:0016567	ISO:MGI
stem cell population maintenance	GO:0019827	IMMGI
transcription by RNA polymerase II	GO:0006366	IMMGI









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31606
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.24|      84|     193|     161|     259|       1
---------------------------------------------------------------------------
  161-  259 (109.47/130.79)	ClQCLEKTLSSTKNRALL...HIAKLeeASSWTAIEHSLLKLGEIlANL.SNPQLRSQAErcGTLIRSIPSMLSVHSEQlhktgfPtiHALILLEGTMnLTGE
  357-  444 (138.77/103.84)	C.DCTNFLLQECNKQGLLsevNFASL..VGKRTADRDPQLKSSEN.ANIqPNPGLILRAE..PTVTNILKTMDADHSKS......P..EGLLGVLGHM.LSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.41|      14|      16|     583|     596|       2
---------------------------------------------------------------------------
  583-  596 (23.68/15.28)	ILEILNAWENGV..LA
  600-  615 (17.73/ 9.68)	IQKITDNIKGKVcsLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.08|      47|     192|     702|     755|       3
---------------------------------------------------------------------------
  702-  755 (73.27/62.21)	KRPIKEVLTDIFakVLEKGWVDSRSIHIldtllHMGGVYWFCNNLIKELLKETR
  892-  938 (83.81/53.74)	RDPLNRVLANLF..LLISSILGSRTAGP.....HTQFVQWFMEECVGCLEQDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.02|      13|      28|     307|     319|       4
---------------------------------------------------------------------------
  307-  319 (22.82/17.44)	AFTY.LKIPQVLVK
  337-  350 (18.20/12.13)	AFEFlLKLTPLLDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.11|      53|     116|     643|     699|       6
---------------------------------------------------------------------------
  643-  699 (84.36/64.49)	QLagpLYSENTLQFYNERVVIMNSILEHMCADVlQQTATQIKFPSTGVDTMPYWNLL
  764-  816 (93.75/58.79)	QL...LYSIFCLDMQQVTLVLLGHILPGLLTDS.SKWHSLMDPPGTALAKLAVWCAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.52|      33|      68|     479|     514|       7
---------------------------------------------------------------------------
  479-  514 (50.87/45.28)	ESTKTASVRALLFDISFLMLChvaQTYGSEVILSES
  548-  580 (57.65/41.88)	DSTKVESLVALLNNSSEMKLV...QMKWHEACLSIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31606 with Med24 domain of Kingdom Metazoa
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