<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31606

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSCSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGTPAPGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAERCGTLIRSIPSMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGEKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEVNFASLVGKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYVSLFPVEDMQPSKLMRLLSSSDDDANILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVGCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length987
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.07
Grand average of hydropathy0.026
Instability index47.49
Isoelectric point6.38
Molecular weight109983.82
Publications
PubMed=10406464
PubMed=11471062
PubMed=16141072
PubMed=19468303
PubMed=15489334
PubMed=12093747
PubMed=11934987
PubMed=17242355
PubMed=21183079

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription. 
ECO:0000250	
ECO:0000269	PubMed:10406464
ECO:0000269	PubMed:12093747
GO - Cellular Component
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	ISO:MGI
ubiquitin ligase complex	GO:0000151	ISO:MGI
GO - Biological Function
histone acetyltransferase activity	GO:0004402	ISO:MGI
protein-containing complex binding	GO:0044877	ISO:MGI
thyroid hormone receptor binding	GO:0046966	ISO:MGI
transcription coactivator activity	GO:0003713	ISO:MGI
transcription coregulator activity	GO:0003712	ISO:MGI
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISO:MGI
positive regulation of transcription, DNA-templated	GO:0045893	ISO:MGI
protein ubiquitination	GO:0016567	ISO:MGI
stem cell population maintenance	GO:0019827	IMMGI
transcription by RNA polymerase II	GO:0006366	IMMGI

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31606
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.24|      84|     193|     161|     259|       1
---------------------------------------------------------------------------
  161-  259 (109.47/130.79)	ClQCLEKTLSSTKNRALL...HIAKLeeASSWTAIEHSLLKLGEIlANL.SNPQLRSQAErcGTLIRSIPSMLSVHSEQlhktgfPtiHALILLEGTMnLTGE
  357-  444 (138.77/103.84)	C.DCTNFLLQECNKQGLLsevNFASL..VGKRTADRDPQLKSSEN.ANIqPNPGLILRAE..PTVTNILKTMDADHSKS......P..EGLLGVLGHM.LSGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.41|      14|      16|     583|     596|       2
---------------------------------------------------------------------------
  583-  596 (23.68/15.28)	ILEILNAWENGV..LA
  600-  615 (17.73/ 9.68)	IQKITDNIKGKVcsLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.08|      47|     192|     702|     755|       3
---------------------------------------------------------------------------
  702-  755 (73.27/62.21)	KRPIKEVLTDIFakVLEKGWVDSRSIHIldtllHMGGVYWFCNNLIKELLKETR
  892-  938 (83.81/53.74)	RDPLNRVLANLF..LLISSILGSRTAGP.....HTQFVQWFMEECVGCLEQDSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.02|      13|      28|     307|     319|       4
---------------------------------------------------------------------------
  307-  319 (22.82/17.44)	AFTY.LKIPQVLVK
  337-  350 (18.20/12.13)	AFEFlLKLTPLLDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.11|      53|     116|     643|     699|       6
---------------------------------------------------------------------------
  643-  699 (84.36/64.49)	QLagpLYSENTLQFYNERVVIMNSILEHMCADVlQQTATQIKFPSTGVDTMPYWNLL
  764-  816 (93.75/58.79)	QL...LYSIFCLDMQQVTLVLLGHILPGLLTDS.SKWHSLMDPPGTALAKLAVWCAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.52|      33|      68|     479|     514|       7
---------------------------------------------------------------------------
  479-  514 (50.87/45.28)	ESTKTASVRALLFDISFLMLChvaQTYGSEVILSES
  548-  580 (57.65/41.88)	DSTKVESLVALLNNSSEMKLV...QMKWHEACLSIS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31606 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA