<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31604

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKENNKILQLIYVAWRERWTDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYLKHSLCAHLVSHAAVIRCIAKYDKLERVYCITALLEFLASIVDGVTCRIKSEEAVLPSSVVHLVYWLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLSQQQFLLSMLYVGCHEELEICGRIRDKYATIKGSLTNSNFTLNAPQVEQQLQQLAFIEAKHLEMQPLNPPSTLEKISCCVQPLLAVEVLLNPCKDTSYYVAELQMLQRLKKYSNTRLFYEIIRAGFLTLSNVADTSPDTMWGAFMFFKMPHIIKQLHALQRIPGEQPPPADYIPELVEALELLIEDNLLLDFMDTKCSCNMIEFLLNDWTKQQLVNDVHVKKFASQREAASQLLKKCDNGQQTPSNINFIKRAEVPLSGVLKTLCTNKVQDMVNVLCQVPVGNSFELILSVATVEGRLKTFVSRLIQCNENSKPVPGDLGKLCVIRSTLFDVSFLMLTSIVQTYGSDVVLSERGDSFFEKWVRECMVERNKLKNPRQILALCDDSIVDELLLSFSKPEASQLKPNNLSWQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSVCATSFLCAYMYSVKETELLKPLNMIQQFLAPLTSEELSSQENAKERLALSYQIIRKMQHDVHPAPSTKSRLISHSPLVEQFREVWRTVVDAGHLPVRAAQSLESLLLAGGAAWLSTQLVEQLLACKYTRDMSRTMDVVFAVMHLDIEKTTEALLQYVVAPLILRRQGEDINEPQSLVLARLCVYCIISCLESRKGNGTSALTAMKKRSRSHDDEELAANAAKVRKVIGDGSDNSSDFTDTTTGAGLAALLGSTSTSELRTTPLTLREPLQTSVQHIFAVFLQFVSGDELSPKAVFVYQFISLLVECGGERVAPVLRLLPNGLVQQLLKVLVTDDIKVGLISRLYDLRIQAGRLSAVSDLCLWRNMQMARHSIHL
Length993
PositionTail
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy0.034
Instability index44.52
Isoelectric point6.43
Molecular weight111741.51
Publications
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=12021283
PubMed=16751183
PubMed=18327897

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	ISS:FlyBase

GO - Biological Function
transcription coregulator activity	GO:0003712	IMP:UniProtKB

GO - Biological Process
F:transcription coregulator activity	GO:0003712	IMUniProtKB
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IMFlyBase
positive regulation of programmed cell death	GO:0043068	IMFlyBase
pupal development	GO:0035209	IMFlyBase
regulation of programmed cell death	GO:0043067	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IMUniProtKB
salivary gland histolysis	GO:0035070	IMFlyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      52.44|      10|      82|     568|     577|       1
---------------------------------------------------------------------------
  568-  577 (20.14/13.78)	LKPNNLSWQE
  638-  647 (17.39/10.79)	LKPLNMIQQF
  651-  660 (14.90/ 8.08)	LTSEELSSQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.55|      37|     201|     719|     755|       2
---------------------------------------------------------------------------
  719-  755 (64.90/41.80)	QSLESLLLAGGA......AWLSTQLVEQLLACKYTRD.....MSRTMD
  917-  964 (51.65/31.77)	QFISLLVECGGErvapvlRLLPNGLVQQLLKVLVTDDikvglISRLYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.39|      25|     200|     340|     364|       4
---------------------------------------------------------------------------
  340-  364 (42.93/23.45)	PELVEAL.ELLIEDNLLLDFMDTKCS
  541-  566 (37.46/19.64)	PRQILALcDDSIVDELLLSFSKPEAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.82|      59|     330|     109|     173|       7
---------------------------------------------------------------------------
  109-  173 (88.90/76.44)	VTCRI...KSEEAVLpsSVVHLVYWLLQIFARTVQHYELYGEISAEqsymLDQTCVVIDRLSQQQFLL
  441-  502 (93.92/63.00)	VLCQVpvgNSFELIL..SVATVEGRLKTFVSRLIQCNENSKPVPGD....LGKLCVIRSTLFDVSFLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.79|      47|     813|      16|      62|       8
---------------------------------------------------------------------------
   16-   62 (85.15/55.41)	RER.WTDSQWGIN...IKKVLPRGV..SGDVYNLADCLMQQALIGSTA......NPLVL
  796-  819 (22.81/ 9.57)	...................VLARLC.....VYCIISCLESRKGNGTSA...........
  826-  884 (53.83/32.38)	RSRsHDDEELAANaakVRKVIGDGSdnSSDFTDTTTGAGLAALLGSTStselrtTPLTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31604 with Med24 domain of Kingdom Metazoa
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