<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31604

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKENNKILQLIYVAWRERWTDSQWGINIKKVLPRGVSGDVYNLADCLMQQALIGSTANPLVLNYLKHSLCAHLVSHAAVIRCIAKYDKLERVYCITALLEFLASIVDGVTCRIKSEEAVLPSSVVHLVYWLLQIFARTVQHYELYGEISAEQSYMLDQTCVVIDRLSQQQFLLSMLYVGCHEELEICGRIRDKYATIKGSLTNSNFTLNAPQVEQQLQQLAFIEAKHLEMQPLNPPSTLEKISCCVQPLLAVEVLLNPCKDTSYYVAELQMLQRLKKYSNTRLFYEIIRAGFLTLSNVADTSPDTMWGAFMFFKMPHIIKQLHALQRIPGEQPPPADYIPELVEALELLIEDNLLLDFMDTKCSCNMIEFLLNDWTKQQLVNDVHVKKFASQREAASQLLKKCDNGQQTPSNINFIKRAEVPLSGVLKTLCTNKVQDMVNVLCQVPVGNSFELILSVATVEGRLKTFVSRLIQCNENSKPVPGDLGKLCVIRSTLFDVSFLMLTSIVQTYGSDVVLSERGDSFFEKWVRECMVERNKLKNPRQILALCDDSIVDELLLSFSKPEASQLKPNNLSWQETCLNLPGVLHHVLIAWEQETLSSADVKSILDNIKRRLFSFSVCATSFLCAYMYSVKETELLKPLNMIQQFLAPLTSEELSSQENAKERLALSYQIIRKMQHDVHPAPSTKSRLISHSPLVEQFREVWRTVVDAGHLPVRAAQSLESLLLAGGAAWLSTQLVEQLLACKYTRDMSRTMDVVFAVMHLDIEKTTEALLQYVVAPLILRRQGEDINEPQSLVLARLCVYCIISCLESRKGNGTSALTAMKKRSRSHDDEELAANAAKVRKVIGDGSDNSSDFTDTTTGAGLAALLGSTSTSELRTTPLTLREPLQTSVQHIFAVFLQFVSGDELSPKAVFVYQFISLLVECGGERVAPVLRLLPNGLVQQLLKVLVTDDIKVGLISRLYDLRIQAGRLSAVSDLCLWRNMQMARHSIHL
Length993
PositionTail
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.07
Grand average of hydropathy0.034
Instability index44.52
Isoelectric point6.43
Molecular weight111741.51
Publications
PubMed=10731132
PubMed=12537572
PubMed=12537569
PubMed=12021283
PubMed=16751183
PubMed=18327897

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes. 
ECO:0000269	PubMed:16751183
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
nucleus	GO:0005634	ISS:FlyBase
GO - Biological Function
transcription coregulator activity	GO:0003712	IMP:UniProtKB
GO - Biological Process
F:transcription coregulator activity	GO:0003712	IMUniProtKB
ecdysone-mediated induction of salivary gland cell autophagic cell death	GO:0035072	IMFlyBase
positive regulation of programmed cell death	GO:0043068	IMFlyBase
pupal development	GO:0035209	IMFlyBase
regulation of programmed cell death	GO:0043067	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IMUniProtKB
salivary gland histolysis	GO:0035070	IMFlyBase

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      52.44|      10|      82|     568|     577|       1
---------------------------------------------------------------------------
  568-  577 (20.14/13.78)	LKPNNLSWQE
  638-  647 (17.39/10.79)	LKPLNMIQQF
  651-  660 (14.90/ 8.08)	LTSEELSSQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.55|      37|     201|     719|     755|       2
---------------------------------------------------------------------------
  719-  755 (64.90/41.80)	QSLESLLLAGGA......AWLSTQLVEQLLACKYTRD.....MSRTMD
  917-  964 (51.65/31.77)	QFISLLVECGGErvapvlRLLPNGLVQQLLKVLVTDDikvglISRLYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.39|      25|     200|     340|     364|       4
---------------------------------------------------------------------------
  340-  364 (42.93/23.45)	PELVEAL.ELLIEDNLLLDFMDTKCS
  541-  566 (37.46/19.64)	PRQILALcDDSIVDELLLSFSKPEAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.82|      59|     330|     109|     173|       7
---------------------------------------------------------------------------
  109-  173 (88.90/76.44)	VTCRI...KSEEAVLpsSVVHLVYWLLQIFARTVQHYELYGEISAEqsymLDQTCVVIDRLSQQQFLL
  441-  502 (93.92/63.00)	VLCQVpvgNSFELIL..SVATVEGRLKTFVSRLIQCNENSKPVPGD....LGKLCVIRSTLFDVSFLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.79|      47|     813|      16|      62|       8
---------------------------------------------------------------------------
   16-   62 (85.15/55.41)	RER.WTDSQWGIN...IKKVLPRGV..SGDVYNLADCLMQQALIGSTA......NPLVL
  796-  819 (22.81/ 9.57)	...................VLARLC.....VYCIISCLESRKGNGTSA...........
  826-  884 (53.83/32.38)	RSRsHDDEELAANaakVRKVIGDGSdnSSDFTDTTTGAGLAALLGSTStselrtTPLTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31604 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA