<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31603

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINIKKNCPKGATWDYLNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRELCVKSLLEIMDMFSNRLSCHGKAEECIGLCRAMLCTVVWLLQGCAWYCERLRDPNDFSALESSLRACLERMANLLHSTKNRALVHIARLEEQASWTNVEQAVLKLTENLSAVTNPTLKESLEECVSLVKSIPQMLCLQCDPPVHTTFPSVHAFIMLEGTMNLTGETQPLVEQLMMIKRMQRIPAPLFVLEIWKACFTGLIESPEGNEELKWTAFTFLKIPQVLLRLKKYPQGEKTQDFTEDVNVAFEYLLNLTPLLDKADQRCNCDCLSLLLQECNKLGLLSEANTATLTAKRSEDREHAPRLKTAENANIQPNPGLILRAEPTVTNILKTVDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFIKLNEFPKHISGEGSKSASVRALLFDISFLMLCHVVQTYGSEVILSDPSPSSETPFFETWLQTCMPEEGKTLNPDHPCFRPESGKVESLVALLNSSSEMKLVQMKWHEICLSTPAAILEVLNAWENGVLSVEAVQKITDNIKGKVCSMAICAVAWLVAHVRMLGLDEREKPQTMIRQLMTPMSGENTLQFYHERVVIMSSILEHMCADVFQQTGLSLRPAVEGQEPIPYRNLLPARLPIRQALQSQFRKVLEKGWVDSHAFHLFENLLHMGGVFWFTNNLVKELLKETRKEWASRVVELLYSIFCLDTQQITLTLLGHILPRLLTDPAHWHSLADPPGRALAKLSVWCALSSYSSHHKGQASARQRKRHREDIEDYTSLFPLDDTQPSKLMRLLSSNEDENSMLSSPGDRSISSSLSASQLHTVNMRDPLNRVLANLFLLISSQLGSKTAGPHTQFVQSFVEECVDCSEQGSRSSILQFMPFTMISELVKLQSLAKPKTVLSITDLSLPLGRRMAAKAIAAL
Length989
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.07
Grand average of hydropathy-0.071
Instability index47.56
Isoelectric point6.62
Molecular weight110860.45
Publications
PubMed=16396911
PubMed=16582438

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for proliferation of enteric nervous system precursors. Required for the development of dopaminergic amacrine cells and rod photoreceptor cells in the retina. 
ECO:0000250	
ECO:0000269	PubMed:16396911
ECO:0000269	PubMed:16582438
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
enteric nervous system development	GO:0048484	IMZFIN
interstitial cell of Cajal differentiation	GO:0061453	IMZFIN
retinal cone cell development	GO:0046549	IMZFIN
thymus development	GO:0048538	IMZFIN

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.40|      26|     115|     421|     446|       1
---------------------------------------------------------------------------
  421-  446 (44.21/23.31)	KTVDADHSK.SPE.GLLGVLGHMLSGKS
  537-  564 (35.19/17.17)	KTLNPDHPCfRPEsGKVESLVALLNSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.21|      25|      85|     203|     237|       3
---------------------------------------------------------------------------
   91-  113 (25.59/ 6.08)	ELCVKSLLEIMDMFS...nrLS.C........HGK....
  115-  150 (26.58/ 6.88)	EECIGLCRA...MLCtvvwlLQgCawycerlrDPNDFSA
  213-  237 (49.03/45.56)	EECVSLVKSIPQMLC.....LQ.C........DPPVHTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.40|      20|     395|     288|     311|       6
---------------------------------------------------------------------------
  288-  307 (35.80/27.70)	TGLIESPEGNEELKWT.....AFTF
  315-  339 (29.60/12.28)	LRLKKYPQGEKTQDFTedvnvAFEY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31603 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA