<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31598

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSNQVPASLPVTQ
Length1367
PositionTail
OrganismMus musculus (Mouse)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Mus> Mus.
Aromaticity0.10
Grand average of hydropathy-0.006
Instability index47.38
Isoelectric point6.92
Molecular weight156085.70
Publications
PubMed=11934987
PubMed=14621295
PubMed=16141072
PubMed=15489334
PubMed=15542641
PubMed=14759369
PubMed=16137621
PubMed=15749018
PubMed=21183079
PubMed=20111005

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre- initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:MGI
nucleoplasm	GO:0005654	TAS:Reactome
transcription regulator complex	GO:0005667	ISO:MGI
ubiquitin ligase complex	GO:0000151	ISO:MGI

GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IMMGI
positive regulation of T cell extravasation	GO:2000409	IMMGI
protein ubiquitination	GO:0016567	ISO:MGI
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription, DNA-templated	GO:0006355	ISO:MGI









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31598
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.35|      55|     262|     971|    1026|       1
---------------------------------------------------------------------------
  971- 1026 (97.23/67.44)	IHRFL..ELLPVSKSLETLL..DHLGG..LYKF.HDRPVTYLYNTLHYYEMCLrNRDHLKRKL
 1227- 1288 (81.12/51.13)	IPKFLteALLPVVKTEFQLLyvYHLVGpfLQRFqQERTRCMIEIGVAFYDMLL.NVDQCSTHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.79|      17|     127|     905|     922|       2
---------------------------------------------------------------------------
  905-  921 (35.55/16.43)	KENSPEHWLQSDWHTKH
 1035- 1051 (33.23/14.65)	KDNRPQGWCLSDTYLKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     306.34|      96|     262|     522|     624|       3
---------------------------------------------------------------------------
  522-  624 (152.98/147.86)	PLPMNLLDSLTVHAKMslIHSIATRVIKLAHTKSSValapALVETYSRLLVYMEIESLG...IKGFISQLLPTVFKSHAWGiLHTL...LEMFSHRMHHIQPHY.RVQLL
  787-  889 (153.36/124.78)	PLFLCLLWKMLLETDH..ISQIGYKVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMVWKYNIVT.LDRLilcLAMRSHEGNEAQVCYfIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.05|      34|     128|     929|     963|       4
---------------------------------------------------------------------------
  188-  224 (38.46/19.09)	.RKLYPEGklphwlL.GNLVSDFVDTFRPTARI..NSIC.GR.
  929-  963 (62.02/40.18)	PEKLYFEG......L.AEQVDPPVPIQSPYLPIyFGNVC.LRF
 1063- 1094 (52.57/28.74)	PEDSYYCK......LiGRLVDTMAG.KSPG.P..FPN.CdWRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      32|     339|     348|       6
---------------------------------------------------------------------------
  339-  348 (18.69/10.31)	IFFVLFQFAS
  372-  381 (19.45/11.05)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.04|      36|     373|     721|     778|       7
---------------------------------------------------------------------------
   29-   64 (66.34/32.38)	TPEDEKTKLISCL.AAFRQFW..SGLSQESH........EQCVQW.........IV
  723-  778 (44.71/62.75)	TPHNWASHTLSCFpAPLQAFFkqNNVPQESRfnlkknveEEYRKWksmtdeneiIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.44|      55|     867|     268|     322|       8
---------------------------------------------------------------------------
  268-  322 (98.72/65.79)	ALLRYVLE.QP.YSRDMVC...NMLGL..NKQHKQRCPVLEDQLVDLVVYAMERSETE......EKFD
 1125- 1192 (69.72/44.22)	ALLNVVLKsQPlVPRENITawmNAIGLiiTALPEPYWIVLHDRIVNVISSSSLTSETEwvgypfRLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.07|      10|      27|     135|     144|      12
---------------------------------------------------------------------------
  135-  144 (15.60/12.88)	RDLLKAILEK
  164-  173 (16.48/14.14)	REVIAYILER
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31598 with Med23 domain of Kingdom Metazoa
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