<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31597

Description Isoform 4 of Mediator of RNA polymerase II transcription subunit 23
SequenceMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ
Length1359
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.10
Grand average of hydropathy-0.009
Instability index45.43
Isoelectric point7.09
Molecular weight156472.21
Publications
PubMed=10235266
PubMed=10353252
PubMed=9989412
PubMed=10574462
PubMed=11230166
PubMed=14574404
PubMed=15489334
PubMed=10235267
PubMed=10993082
PubMed=11867769
PubMed=14759369
PubMed=15175163
PubMed=15989967
PubMed=17000779
PubMed=16595664
PubMed=19413330
PubMed=20111005
PubMed=21269460
PubMed=21868677

Function

Annotated function Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	TAS:Reactome
transcription regulator complex	GO:0005667	IDA:MGI

GO - Biological Function
transcription coactivator activity	GO:0003713	TAS:ProtInc

GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
regulation of transcription, DNA-templated	GO:0006355	IDA:MGI
transcription initiation from RNA polymerase II promoter	GO:0006367	TAS:ProtInc









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.17|     105|     260|     512|     624|       1
---------------------------------------------------------------------------
  512-  624 (165.13/133.94)	TNCMASGSiTPLPMNLLDSLTVHAKMslIHSIATRVIKLAHAKSSValapALVETYSRLLVYMEIESLG...IKGFISQLLPTVFKSHAWGiLHTL...LEMFSYRMHHIQP.HYRVQLL
  778-  889 (171.04/114.65)	THFSMQGS.PPLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSAGgqqLNKCIEILNDMVWKYNIVT.LDRLilcLAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.40|      26|     524|     403|     428|       2
---------------------------------------------------------------------------
  403-  428 (51.40/31.80)	YPEKEYI........PVPDINKPQSTHAFAMTCI
  928-  961 (46.00/27.65)	YPEKLYFeglaeqvdPPVQIQSPYLPIYFGNVCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.98|      56|     904|     325|     399|       3
---------------------------------------------------------------------------
  344-  399 (99.64/75.70)	FQFASFPHMV...LSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKN...ALADFLPVMK.LF
 1243- 1305 (90.34/41.05)	FQLLYVYHLVgpfLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNymdPICDFLYHMKyMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.60|      12|     255|     971|     982|       5
---------------------------------------------------------------------------
  971-  982 (22.31/13.52)	IHRFLE..LLPVSK
 1227- 1240 (17.30/ 8.67)	IPKFLTevLLPIVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.83|      21|     372|     652|     682|       6
---------------------------------------------------------------------------
  652-  675 (29.84/39.73)	LITALGSSevqPQFTRFLSDPKTV
  687-  707 (33.98/17.18)	LILTLARA...THVTDFFTGSDSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.67|      28|     711|      29|      56|       7
---------------------------------------------------------------------------
   29-   56 (52.01/34.47)	TPEDEKTKLISCL.GAFRQFW..GGLSQESH
  723-  753 (45.66/29.27)	TPHNWASHTLSCFpGPLQAFFkqNNVPQESR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.36|      15|      16|    1036|    1051|       8
---------------------------------------------------------------------------
 1036- 1051 (28.12/23.89)	DNRPQG.WCLSDTYLkC
 1054- 1069 (27.23/17.39)	NAREENpWVPDDTYY.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.05|      10|      27|     135|     144|       9
---------------------------------------------------------------------------
  135-  144 (15.61/ 8.94)	RDLLKVILEK
  164-  173 (16.44/ 9.78)	REVIAYILER
---------------------------------------------------------------------------











Associated diseases
Disease
Ras-active lung cancer	PMID:22988093
skin-related diseases	PMID:28834744
anabolic bone formation and related diseases	PMID:27033977
metabolic diseases	PMID:25223702
oral or genital skin lesions  meningitis	PMID:23950709
neurodegenerative diseases	PMID:25564654
Alzheimers disease	PMID:25835418



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31597 with Med23 domain of Kingdom Metazoa
Unable to open file!