<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31595

Description Isoform 2 of Mediator of RNA polymerase II transcription subunit 23
SequenceMETQLQSIFEDVVKTEVIEEAFAGMFMDSPEDEKTKLTSCLGAFRQFWSTLPQESHEQCVQWIVRFIHGQHSPKRIAFLYDCLAMAVETSLLPPRMVCQALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPNFVSSAVVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLCPEGALSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPYDKDLFDPQTGLLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALGDFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGSMRITLPGTNCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMTYHKKYPEKLYFEGLAEQVNPPIQLQSQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKCGMNAREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSAVLSSGSDWLGYPFQLLDFTACHQSYSEMHCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHSNHLAYMDPICDFLYHIKYMFTGDSVKDQVERIICSLRPAMRLRLRFITHISKMEPAAVPVSNSSSVQQTSSASSPTAQSTAGAAIPLSVTQ
Length1352
PositionTail
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio.
Aromaticity0.10
Grand average of hydropathy-0.008
Instability index45.03
Isoelectric point7.20
Molecular weight156880.29
Publications
PubMed=23594743

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
circulatory system development	GO:0072359	IMZFIN
negative regulation of neurogenesis	GO:0050768	IMZFIN
pigmentation	GO:0043473	IMZFIN
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.60|      16|      17|     995|    1010|       1
---------------------------------------------------------------------------
  995- 1010 (31.60/20.81)	YKFHDRPVTYLYNTL.H
 1012- 1028 (25.00/14.95)	YERHLRDRTNLKRKLvH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.62|      13|      17|     257|     269|       2
---------------------------------------------------------------------------
  257-  269 (25.49/16.89)	PYDKDLFDPQTGL
  277-  289 (26.13/17.52)	PYSRDMVCNMLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.70|      15|      20|     467|     485|       3
---------------------------------------------------------------------------
  467-  485 (20.72/23.12)	LPMTdykiALLCNAYSTNS
  490-  504 (25.98/15.77)	LPMG....VLVETIYGNGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.93|      31|     785|     174|     204|       4
---------------------------------------------------------------------------
  174-  204 (56.63/42.31)	NACL..LPAY.FAVTEIRKLCP.....EGALSHWLLGSL
  891-  917 (42.29/29.26)	...L..KPND.FR.NRVSDFVK.....ENAPEHWLQSDW
  958-  994 (33.01/20.81)	NVCLrfLPVFdIVIHRFLELLPvskslETLLDH..LGGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.04|      18|      20|    1035|    1053|       5
---------------------------------------------------------------------------
 1035- 1053 (31.30/26.05)	KDNRTPGWCLSETYLkCGM
 1054- 1071 (34.74/23.71)	NAREDNVWIPDDTYY.CKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.85|      34|     785|      69|     102|       6
---------------------------------------------------------------------------
   69-  102 (63.06/35.57)	GQHSPKRIAFLYD...............CL..AMAVETSLLP.......PRMVCQALI
  783-  820 (33.45/15.72)	.QGSPP....LFL...............CLlwKMLLETDHINqigfrvlERIGARALV
  840-  886 (47.34/25.04)	GQQLNKCIEILNDmvwkynivtldrlilCL..AMRSHEG..N.......EAQVCYFII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.09|      39|     716|     564|     637|       7
---------------------------------------------------------------------------
  518-  561 (53.62/45.64)	GSVTPLPMNLLDSltvHA.............KMSLIHSiATRVIKLAHAKsSLALAP
  583-  634 (63.47/52.46)	GFISQLLPNVFKS...HAwgilhtllemfsyRMHHIQP.HYRVQLLSHLH.SLAAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.50|      31|      53|    1235|    1268|      10
---------------------------------------------------------------------------
 1235- 1268 (46.01/38.68)	LKPIVKTEFQLLYVYhlVGPFLQRfQQERTRCML
 1291- 1321 (57.49/35.64)	MDPICDFLYHIKYMF..TGDSVKD.QVERIICSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      12|      20|     351|     362|      11
---------------------------------------------------------------------------
  351-  362 (21.06/10.28)	HMVLSLHQKLAG
  371-  382 (22.76/11.65)	HLMWVLLQFISG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31595 with Med23 domain of Kingdom Metazoa
Unable to open file!