<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31592

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMDQSQRTVAATPSSSRSYQFHPARAAIIDLFNLYLGRGSRQKPDESLRDPPNKSQKRVHAPNRDLPPRNEQFLLDFELLQSQFNDPEQLRTITESVLISLVVQCSNHAPRAEFLLFALRTLCRISYINWDTFLPSLLSSVSAAEASLSQGVQAAAATAGSSATSSQSVVPVSVNPTSLLPSAHGIGSPSASEVKSVENGQQIARAGQIVRENAMRNSQRIRAAAVNSLRQLSCKIILIGVESSLKPVTHAEIFQYMMNWLVNWDRRDLGTEDSVGKSWRSEKTLAEWLRSCLDVIWLLVEEGESRIPFYELLRSGLQFIENIPDDEALFTLIMEIHRRRDAMAMHMLMLDQHLHCPSFGTHRIVSQITANVPPEAVPHLRHSPITYPSVLGEPLYGEDLAMSIPKGSLDWERAVRCIRHAIRTTPSPDWWKRVLVVAPCYRPSTQAGPIPGAVFTSDMICEAIIDRIVELLKLTNSGNDCFGIDLVSVTFPPLYADANCWQEWLVFSDIFFFLIKSGCTDFVDFIDKLVLRLNGVDNHILRTNHVTWLLAQIIRVELVMTALNSDAKKVETTRKILSFHREDRNSDPNNPQSVLLDFVSSCQNLRIWSLSTTTRAYLNNEQLLKGKQIDEWWRSKGERMMDYMNMDDRSIGMFWVVSYTMAQPACETVINWLSSAGMAELPGLQPNDRVMMTQEVTPLPMSLLSGFSMNLCLKLALQMEEALFVSQVVPSIAMVETYTRLLLISPHSMFRSHFSQLAQRNASLLSKPGVTLLVLEILNYRLLPLYRYQGKSKTLMYDVTKIISALKGKRGDHRIFRLAENLCMNLILSLRDFFSVKREGKGPTEFTETLNRITIMTLAITIKTRGIADPDHMVYLQTMLEQILATSQHTWSEKTMRHFPSLLRETLKGRVDKRGLSIQAWQQAETTVINQCTQLLSPSAEPAYVSTYLSHSFPQHRQYLCAGACLLMQGHAENINSTNLARVLREVSPEEVTANIYTLVDVLLHHVHVDLQQGQSLEAVLDKAGANLAFFFWTHEMLPLDIFLLALIDRDDDPHALIIAMSLLKTPDLLLRIKNYCQNRGSPEHWLVTQVFKRNELQKALGNHLSWKDRYPTFFDDIAARLLPVIPLVLYRLIENNAMEQADNLLLAHSHFLAYHPLRFTFVRDILAYFYGHLPGKLVLRMLKVLDLSKIPFSESFPQYISPTGAPVCPPLDYFASLLLNLVNNVIPPLSSSSNCSSRSGSMADILNSSARPPHGKTPGTSQPGPANASEGQKAFYQIQDPGTYTQLVLETAVIEILSLPVSAAQIVSSLVQIIVNIQSTLIQSGNGFHGAANGVGQGSVLPTSPSGGSTDSMSASRSTCLIPGINTASFVSRSGYTCQQLSCLLIQACGLLLAQLPPDFHVQLYLEAARVTRETWWLKDGKRSQGELDSAVGYALMDPTWAAQDNTSTAIGNIVALLHAFFSNLPQEWLDGTNAIITNLRPVTSVAMLRVVFRIMGPLLPRLASTHTLFNKTLMLLLSALVDVFGKTAQTTAPVEASQIADLIDFLHHIIHYEGQGGAVQTSSKPRPDILALIGRAAETLRPDVQHLLAHLKTNPNSSIYAAAHQQNTAKTNTS
Length1615
PositionTail
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.08
Grand average of hydropathy-0.037
Instability index43.31
Isoelectric point6.96
Molecular weight180094.14
Publications
PubMed=11130712
PubMed=27862469
PubMed=17560376
PubMed=22021418

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
transcription regulator complex	GO:0005667	IBA:GO_Central
GO - Biological Function
GO - Biological Process
positive regulation of gene expression	GO:0010628	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31592
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     364.35|     103|     474|     582|     745|       3
---------------------------------------------------------------------------
  259-  307 (47.97/ 8.71)	................WLVNWDRRD..LGTED.SVGK.....SWRSEKTLAEwlRSCLDVIW...LLVEEGESRIP.............................................
  616-  723 (175.04/214.43)	YLNNEQLLKgkqiDEWWRSKGERMMDYMNMDDRSIGM.....FWVVSYTMAQ..PACETVIN...WLSSAGMAELPG..LQPNDRVMMT.QEVTPLPMsLLSGFSMNLCLKLALQMEEALF
 1405- 1510 (141.34/74.39)	YLEAARVTR....ETWWLKDGKRSQGEL...DSAVGYalmdpTWA.....AQ..DNTSTAIGnivALLHAFFSNLPQewLDGTNAIITNlRPVTSVAM.LRVVFRIMGPLLPRLASTHTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.36|      68|     548|     988|    1059|       4
---------------------------------------------------------------------------
  988- 1059 (104.25/92.45)	PEEvTANIYTLVDVLLHHVHVDlQQGQSLEAVLDKAGANLAFFFWTHEMLPLDI.FLLALIdrDDDPHALIIA
 1534- 1602 (113.11/82.98)	PVE.ASQIADLIDFLHHIIHYE.GQGGAVQTSSKPRPDILALIGRAAETLRPDVqHLLAHL..KTNPNSSIYA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.00|      35|     416|     932|     968|       5
---------------------------------------------------------------------------
  932-  968 (60.26/49.14)	TQLLSPSAEPAYVSTYLSHSFPQHRQYLC.agACLLMQ
 1350- 1387 (57.75/39.88)	TDSMSASRSTCLIPGINTASFVSRSGYTCqqlSCLLIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.82|      14|     456|     399|     449|       6
---------------------------------------------------------------------------
  375-  388 (28.12/24.28)	AVPHLRHSPITYPS
  413-  426 (26.70/36.79)	AVRCIRHAIRTTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.00|      33|     406|     732|     784|      11
---------------------------------------------------------------------------
  749-  784 (50.94/29.93)	FRSHFSQ..LAQRNASLlskPG.VTLLVLEILNYRLLPL
 1157- 1192 (49.07/34.33)	LRFTFVRdiLAYFYGHL...PGkLVLRMLKVLDLSKIPF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31592 with Med23 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) YQFHPARAAIIDLFNLYLGRGS
18
39