<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31591

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMSTDTQIIKLVEEILCEKTNDYDYEGPMPDEAELQKRAEDGMKKFATVFAGMSQEVKENALRSCLIHVAGINHRNKVRKHMQVLKDLVGKGIIPARLLCEQIMSSEKLVYQNQSFWIECFQVVRRVIGGVDYKGVREIMKCCKEKALSFPSGISSSILPQMLELTEVIEHIFNRNACLLPAYFIINEIQKADYQDTHWRIANLIANFIEEFVIVAQMLSIIGHSSMLPIVEHSSYADNLINPWKLDPTTLKLALRGNLPYEPELLQPQIKLLRFVLEQPYSRDMVCSMLNLQKTQKQKCMALEEQLVWLVMCAMECSEKEPVHTVDGEISSHTQWVWLHLSSQLIYFVLFQFATFQNIVNTLHDKLAVSNLRRGRDHLMWVLLQYISGSIQRNSITNFLPILKLYDSLYPEKEPLPVPDYNNPLCTHQMAPTCIWIHLLKRAQSEHYNINRSIPTALKLHHEFLQHLVMPNNNATLCMGSDYRLALLCNAYSTNPDYFSRPMAALIETILGNCKNPSAGGGSTSATQPLPTVPLSMSVLDSLTIHSKMSLIHSIVTHMIKQAQSKTTVPNTNNMAPALVETYSRLLVYTEIESLGIKGFLGQLLPQVFKSAAWGILYTLLEMFSYRMHHIQPHYRVQLLSHLHSLASVPHTNQMQLHSCVESTALRLITGLGSVEVQAQMSRYVTEQKAPGNIVSAESEELNRALILTLARSMQITGTGNDPQSTTWCKELLNSIMQNTPHTWSQHTLQCFPPVLNDLVVQHNVPKENKQLLKKSVDEEYRNWTSMSNENDIIGHFGTAGTPGTPPLFLCLLFKMIVETDTISPVAYKILERIGARALSAHLRKLCDYLVFEVSNSGDGAHVNKCVDTINDMIWKYNIITIDRLVLCLSLRTLEGNEAQVSFCIIQLLLLKTSEFRNRLQEFVSINSPEHWKQNNWHERHLAFHQKFPEKFTPDESVSHPSLPVYFGNVCLRFLPVLDITIHRYLEVPAAMSKTLDVLLDHLGPLYKFHDRPITYLYNTLHYYERMLRDRPQLKKRLVGTVIGSLKDVRPDNWAVTEQYQSYMSKKDDAVNWMPDLNYYIYLVRRMQDTIDGTNIFPGTDWRFNEFPNPPAHALYVTCVELLGLPVGPQGVANSLIDVVVKGYPVIPSQSVHNWINTIGLIMAALPESYWGVIYERLREVISCPQMTDWLHRQSPFELFNFKIVREAMLEKNYVVILAIAQSILHHSGIGQISTVTEHIKENFKPIIKTEYQLIYLCHLVGPFLNRLCAERSRAVSDITLILYELLEQVDKAQPSLALKYMDPICDLLYHIKYMFIGDMMKSDLEAIIRRLRPALQMRLRFITRLNVDEIGVDQQNVDASAAGQGPAQGGPQSQQPQTTGQAGGQPSVPQQQQQTQQQQPQQQQQVQQQ
Length1409
PositionTail
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.08
Grand average of hydropathy-0.153
Instability index50.07
Isoelectric point6.71
Molecular weight160829.18
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31591
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     228.94|      78|      90|     487|     571|       1
---------------------------------------------------------------------------
  487-  571 (113.08/86.79)	LCNAYSTNPDYfsRPMAAL.IETILGNCKnPSAggGSTSATQPLPTVpLSM.SV.LDSLTIHSKMSL...IHSI..VTHmIKQAQSKTTVPNT
  578-  663 (115.86/64.87)	LVETYSRLLVY..TEIESLgIKGFLGQLL.PQV..FKSAAWGILYTL.LEMfSYrMHHIQPHYRVQLlshLHSLasVPH.TNQMQLHSCVEST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.46|      16|      17|    1362|    1378|       2
---------------------------------------------------------------------------
 1362- 1377 (32.80/19.00)	AGQGPA....QGGPQSQQPQ
 1382- 1401 (26.66/ 9.69)	AGGQPSvpqqQQQTQQQQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.82|      11|      17|    1123|    1133|       3
---------------------------------------------------------------------------
 1123- 1133 (22.83/11.52)	GLPVGP.QGVAN
 1142- 1153 (18.99/ 8.41)	GYPVIPsQSVHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.83|      15|      17|    1049|    1065|       4
---------------------------------------------------------------------------
 1049- 1063 (29.98/19.38)	RPD..NWAVTEQYQSYM
 1066- 1082 (25.85/ 9.69)	KDDavNWMPDLNYYIYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.50|      41|     152|     775|     849|       7
---------------------------------------------------------------------------
  802-  849 (59.53/90.90)	PGTPPLF..LCLLFKMIVETDTispvaYKILErIGArALSAHLRKLCDYL
  960- 1002 (68.97/30.54)	PSLPVYFgnVCLRFLPVLDITI.....HRYLE.VPA.AMSKTLDVLLDHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.86|      38|     293|     144|     182|       8
---------------------------------------------------------------------------
  144-  182 (63.64/38.52)	EKALSFPSGISSSIlPQMLEL.TEVIEHIF..NRNA..CLLPAY
  440-  482 (56.22/29.86)	KRAQSEHYNINRSI.PTALKLhHEFLQHLVmpNNNAtlCMGSDY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31591 with Med23 domain of Kingdom Metazoa
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