Description | Mediator of RNA polymerase II transcription subunit 22 |
Sequence | MSNQVLLDKLDRTTETLSNTLIHLAKLSDIEFGGKDTEQPRSSSGLATVSSSGVQMSNNYTMQLIKGIQDLLVITRSIREKWVLSQLPENEELSMFESEETLENCRKLVQESMETLLNDMP |
Length | 121 |
Position | Head |
Organism | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.404 |
Instability index | 52.13 |
Isoelectric point | 4.57 |
Molecular weight | 13650.32 |
Publications | PubMed=15229592 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP31584 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) FESEE 2) NYTMQLIKGIQDLLVITRSIREKWVLSQL 3) RSSSGLATVS 4) TLIHLAKLSDIEFGGKDTEQ | 96 59 41 20 | 100 87 50 39 |
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