<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31583

Description Isoform Surf5A of Mediator of RNA polymerase II transcription subunit 22
SequenceMAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA
Length140
PositionHead
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.04
Grand average of hydropathy-0.565
Instability index61.89
Isoelectric point4.56
Molecular weight22220.49
Publications
PubMed=8586415
PubMed=11891058
PubMed=14702039
PubMed=15164053
PubMed=15489334
PubMed=12584197
PubMed=15989967
PubMed=21269460

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
cytoplasm	GO:0005737	TAS:ProtInc
mediator complex	GO:0016592	IDA:MGI

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions
[Q15528<-->Q9P086: MED11]	NbExp=3	EBI-394687,EBI-394704
[Q15528<-->Q9NVC6: MED17]	NbExp=4	EBI-394687,EBI-394562
[Q15528<-->Q9BUE0: MED18]	NbExp=3	EBI-394687,EBI-394640
[Q15528<-->Q6P2C8: MED27]	NbExp=3	EBI-394687,EBI-394603
[Q15528<-->Q9H204: MED28]	NbExp=2	EBI-394687,EBI-514199
[Q15528<-->Q9NX70: MED29]	NbExp=4	EBI-394687,EBI-394656
[Q15528<-->Q9D8C6: Med11]	Xeno	NbExp=2,
[Q15528<-->Q9CQI9: Med30]	Xeno	NbExp=6,
[Q15528<-->Q9D7W5: Med8]	Xeno	NbExp=2,
[Q15528-2<-->O14964: HGS]	NbExp=3	EBI-12954271,EBI-740220
[Q15528-2<-->P42858: HTT]	NbExp=12	EBI-12954271,EBI-466029
[Q15528-2<-->Q96HA8: NTAQ1]	NbExp=3	EBI-12954271,EBI-741158
[Q15528-2<-->P60891: PRPS1]	NbExp=3	EBI-12954271,EBI-749195
[Q15528-2<-->O14530: TXNDC9]	NbExp=3	EBI-12954271,EBI-707554
[Q15528-2<-->O76024: WFS1]	NbExp=3	EBI-12954271,EBI-720609












Repeat regions





Repeats

>MDP31583
No repeats found
No repeats found











Associated diseases
Disease
glomerular diseases	PMID:33208756



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31583 with Med22 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA
164
200










Molecular Recognition Features






MoRF SequenceStartStop




NANANA