Description | Mediator of RNA polymerase II transcription subunit 22 |
Sequence | MQRNLTQSKEALLKSYNSRLKEDIRSMRENFEEIIRLAKGENDTQLSKITQCEQDTYETQVRAANIVRAGESLMKLVSDIKQYLILNDFHSVNEAICSNSTLYRTTQIDRDNKLMAVRDDMAADLYDLEEEYYTSIYK |
Length | 138 |
Position | Head |
Organism | Anopheles gambiae (African malaria mosquito) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.707 |
Instability index | 26.22 |
Isoelectric point | 4.99 |
Molecular weight | 16161.99 |
Publications | PubMed=12364791 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP31572 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 125.27| 41| 55| 20| 62| 1 --------------------------------------------------------------------------- 20- 62 (60.75/49.85) LKEDIRS..MRENFEEIIRlAKGENDTqLSKITQCEQDTYETQVR 76- 118 (64.52/43.42) LVSDIKQylILNDFHSVNE.AICSNST.LYRTTQIDRDNKLMAVR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AICSNSTLYRTTQIDRDNKLMAVRDDMAADLYDLEEEYYTSIYK 2) ALLKSYNSRLKEDIRSMRENFEEIIRLAKGE 3) IKQYLIL 4) LSKITQCEQDTYETQVRAANIVR | 95 11 80 46 | 138 41 86 68 |
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