<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31560

Description Mediator of RNA polymerase II transcription subunit 21
SequenceMADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS
Length144
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.04
Grand average of hydropathy-0.268
Instability index60.02
Isoelectric point4.29
Molecular weight15564.15
Publications
PubMed=8598913
PubMed=8609996
PubMed=14702039
PubMed=15489334
PubMed=9660976
PubMed=9734358
PubMed=9933582
PubMed=10024883
PubMed=15175163
PubMed=15249124
PubMed=15989967

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000269	PubMed:15249124
ECO:0000269	PubMed:9660976
GO - Cellular Component
mediator complex	GO:0016592	IDA:MGI
GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	TAS:ProtInc
transcription coactivator activity	GO:0003713	IDA:MGI
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:MGI
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions
[Q13503<-->Q9UL45: BLOC1S6]	NbExp=3	EBI-394678,EBI-465781
[Q13503<-->Q96GS4: BORCS6]	NbExp=3	EBI-394678,EBI-10193358
[Q13503<-->O14964: HGS]	NbExp=3	EBI-394678,EBI-740220
[Q13503<-->O14901: KLF11]	NbExp=3	EBI-394678,EBI-948266
[Q13503<-->Q13449: LSAMP]	NbExp=3	EBI-394678,EBI-4314821
[Q13503<-->O15481: MAGEB4]	NbExp=6	EBI-394678,EBI-751857
[Q13503<-->Q15648: MED1]	NbExp=3	EBI-394678,EBI-394459
[Q13503<-->Q9NPJ6: MED4]	NbExp=5	EBI-394678,EBI-394607
[Q13503<-->O43513: MED7]	NbExp=3	EBI-394678,EBI-394632
[Q13503<-->Q9NWA0: MED9]	NbExp=5	EBI-394678,EBI-394653
[Q13503<-->Q9NQG6: MIEF1]	NbExp=3	EBI-394678,EBI-740987
[Q13503<-->Q9BVL2: NUP58]	NbExp=3	EBI-394678,EBI-2811583
[Q13503<-->P63208-1: SKP1]	NbExp=5	EBI-394678,EBI-307497
[Q13503<-->A1L4H1: SSC5D]	NbExp=6	EBI-394678,EBI-10172867
[Q13503<-->Q6ZMU5: TRIM72]	NbExp=3	EBI-394678,EBI-2341648
[Q13503<-->Q8N720: ZNF655]	NbExp=3	EBI-394678,EBI-625509

Repeat regions

Repeats

>MDP31560
No repeats found
No repeats found

Associated diseases

Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31560 with Med21 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) PTEEYAQLFAALIARTAKDIDVLIDSLP
50
77