<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31557
Description |
Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MTDRLTQLQVCLDQLVEQFNATVNYVNTNSEPGLLDEDPSSVSNLAANAPIPGVQQQPSQGSGGGSNKQTNAGNSVSNQPSAKAEAESNFENTINELSTDIILKSRQITMLIDSLPGIGVSPESQLNMVEDLAKQLEEVEKERIKKIEEKDKLLKWCESLIVEVATGISESRE |
Length | 173 |
Position | Middle |
Organism | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Debaryomyces.
|
Aromaticity | 0.02 |
Grand average of hydropathy | -0.507 |
Instability index | 46.88 |
Isoelectric point | 4.41 |
Molecular weight | 18785.67 |
Publications | PubMed=15229592
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:EnsemblFungi
|
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi
transcription coactivator activity GO:0003713 IEA:EnsemblFungi
transcription corepressor activity GO:0003714 IEA:EnsemblFungi
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP31557
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.28| 14| 17| 29| 43| 1
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29- 43 (21.23/16.89) NSE.PGlLDEDPSSVS
48- 62 (23.05/13.37) NAPiPG.VQQQPSQGS
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