Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MADRLTQLQDAVNSLADQFCNAIGVLQQCAPPASFSNIQTAINKDQPSNPTEEYAQLFAALIARTAKDVDVLIDSLPSEESTAALQAASLRQLEEENQEAAARLEEVVYRGDALLEKIQTALADIAQSQLRTRSGAPSQQTPPES |
Length | 145 |
Position | Middle |
Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Cypriniformes> Danionidae> Danioninae> Danio. |
Aromaticity | 0.03 |
Grand average of hydropathy | -0.341 |
Instability index | 65.17 |
Isoelectric point | 4.25 |
Molecular weight | 15626.13 |
Publications | PubMed=23594743 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP31556 No repeats found No repeats found |
MoRF Sequence | Start | Stop |
1) LQAASLRQLEE 2) NPTEEYAQLFAALIARTAKDVDVLIDSLP | 85 49 | 95 77 |
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